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基于几根长闪烁光纤和断层重建的高分辨率二维剂量测量装置。

High resolution 2D dose measurement device based on a few long scintillating fibers and tomographic reconstruction.

作者信息

Goulet Mathieu, Archambault Louis, Beaulieu Luc, Gingras Luc

机构信息

Département de Radio-Oncologie et Centre de Recherche en Cancérologie, Hotel-Dieu de Québec, 11 Cote du Palais, Québec, Québec G1R 2J6, Canada.

出版信息

Med Phys. 2012 Aug;39(8):4840-9. doi: 10.1118/1.4736526.

Abstract

PURPOSE

Patient-specific QA of highly conformal radiotherapy treatments are usually conducted using 2D or 3D dosimetry of the incident dose distribution in a water-equivalent phantom. However, dosimeters typically used for this task usually lack in either spatial resolution or dose accuracy. The purpose of this work is to develop and validate a novel type of high resolution 2D dosimeter based on the tomographic reconstruction of the dose projections obtained using long scintillating fibers for the quality assurance of modern radiotherapy techniques such as IMRT.

METHODS

Fifty parallel scintillating fibers were aligned in a 30 cm diameter cylindrical masonite phantom with a 95 cm source-to-surface distance and a 100 cm source-to-fibers distance. The fibers were disposed so that the effective detection area of the scintillating fibers was a 20 cm diameter disk. Both ends of each scintillating fiber were coupled to clear optical fibers to enable light collection by a single CCD camera. Seven IMRT segments and two square fields were acquired using 18 projections over a 170° rotation of the device. Computation of the dose integrals was made for each scintillating fiber using the irradiation of known rectangular reference fields. Dose reconstructions were conducted using a total-variation minimization iterative reconstruction algorithm. Eight monitor units were programmed for each projection and the reconstructed dose grid pixel resolution was set to 1 × 1 mm(2).

RESULTS

3%∕3 mm gamma tests conducted between the reconstructed IMRT dose distributions and the dose calculated with the treatment planning system Pinnacle(3) were on average successful for 99.6% of the dose pixels with a predicted dose of at least 10% of the maximum dose. The dose profiles for both square fields and IMRT segments agreed within 2% to the dose calculated with Pinnacle(3) except in high dose gradient regions, and were comparable to the dose measured using an ionization chamber array (IBA MatriXX) and radiographic films (Kodak XV2).

CONCLUSIONS

Using tomographic reconstruction on the projections acquired with rotating scintillating fibers, we were able to perform water-equivalent 2D dosimetry of square fields and IMRT segments with acceptable accuracy and high spatial resolution. The underlying concept of tomographic dosimetry and the small number of fibers needed to reconstruct a given 2D dose distribution offer new dosimetric possibilities, both applicable to 2D and 3D dosimetry.

摘要

目的

高度适形放射治疗的患者特异性质量保证通常是在水等效模体中对入射剂量分布进行二维或三维剂量测定。然而,通常用于此任务的剂量计在空间分辨率或剂量准确性方面通常存在不足。这项工作的目的是开发并验证一种新型高分辨率二维剂量计,该剂量计基于使用长闪烁光纤获得的剂量投影的断层重建,用于调强放射治疗(IMRT)等现代放射治疗技术的质量保证。

方法

五十根平行的闪烁光纤排列在一个直径30厘米的圆柱形硬质纤维板模体中,源皮距为95厘米,源到光纤距离为100厘米。光纤的布置方式使得闪烁光纤的有效检测区域为直径20厘米的圆盘。每根闪烁光纤的两端都与透明光纤耦合,以便由单个电荷耦合器件(CCD)相机进行光收集。使用该装置在170°旋转范围内的18个投影获取了七个IMRT射野和两个方形射野。使用已知矩形参考射野的照射对每根闪烁光纤进行剂量积分计算。使用总变差最小化迭代重建算法进行剂量重建。为每个投影编程八个监测单位,并将重建剂量网格像素分辨率设置为1×1毫米²。

结果

在重建的IMRT剂量分布与使用治疗计划系统Pinnacle³计算的剂量之间进行的3%∕3毫米伽马测试,对于预测剂量至少为最大剂量10%的剂量像素,平均成功率为99.6%。方形射野和IMRT射野的剂量剖面与使用Pinnacle³计算的剂量在2%以内相符,但在高剂量梯度区域除外,并且与使用电离室阵列(IBA MatriXX)和射线照相胶片(柯达XV2)测量的剂量相当。

结论

通过对旋转闪烁光纤获取的投影进行断层重建,我们能够以可接受的准确性和高空间分辨率对方形射野和IMRT射野进行水等效二维剂量测定。断层剂量测定的基本概念以及重建给定二维剂量分布所需的少量光纤提供了新的剂量测定可能性,适用于二维和三维剂量测定。

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