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DosiMap,一种用于调强放射治疗质量保证的新型二维闪烁剂量仪:两种切伦科夫鉴别方法的特性研究

The DosiMap, a new 2D scintillating dosimeter for IMRT quality assurance: characterization of two Cerenkov discrimination methods.

作者信息

Frelin A M, Fontbonne J M, Ban G, Colin J, Labalme M, Batalla A, Vela A, Boher P, Braud M, Leroux T

机构信息

Laboratoire de Physique Corpusculaire, 6 Bd du Maréchal Juin, F14050 Caen, France.

出版信息

Med Phys. 2008 May;35(5):1651-62. doi: 10.1118/1.2897966.

Abstract

New radiation therapy techniques such as IMRT present significant efficiency due to their highly conformal dose distributions. A consequence of the complexity of their dose distributions (high gradients, small irradiation fields, low dose distribution, ...) is the requirement for better precision quality assurance than in classical radiotherapy in order to compare the conformation of the delivered dose with the planned dose distribution and to guarantee the quality of the treatment. Currently this control is mostly performed by matrices of ionization chambers, diode detectors, dosimetric films, portal imaging, or dosimetric gels. Another approach is scintillation dosimetry, which has been developed in the last 15 years mainly through scintillating fiber devices. Despite having many advantages over other methods it is still at an experimental level for routine dosimetry because the Cerenkov radiation produced under irradiation represents an important stem effect. A new 2D water equivalent scintillating dosimeter, the DosiMap, and two different Cerenkov discrimination methods were developed with the collaboration of the Laboratoire de Physique Corpusculaire of Caen, the Comprehensive Cancer Center François Baclesse, and the ELDIM Co., in the frame of the MAESTRO European project. The DosiMap consists of a plastic scintillating sheet placed inside a transparent polystyrene phantom. The light distribution produced under irradiation is recorded by a CCD camera. Our first Cerenkov discrimination technique is subtractive. It uses a chessboard pattern placed in front of the scintillator, which provides a background signal containing only Cerenkov light. Our second discrimination technique is colorimetric. It performs a spectral analysis of the light signal, which allows the unfolding of the Cerenkov radiation and the scintillation. Tests were carried out with our DosiMap prototype and the performances of the two discrimination methods were assessed. The comparison of the dose measurements performed with the DosiMap and with dosimetric films for three different irradiation configurations showed discrepancies smaller than 3.5% for a 2 mm spatial resolution. Two innovative discrimination solutions were demonstrated to separate the scintillation from the Cerenkov radiation. It was also shown that the DosiMap, which is water equivalent, fast, and user friendly, is a very promising tool for radiotherapy quality assurance.

摘要

诸如调强放射治疗(IMRT)等新的放射治疗技术因其高度适形的剂量分布而具有显著的效率。其剂量分布的复杂性(高梯度、小照射野、低剂量分布等)带来的一个结果是,与传统放射治疗相比,需要更高的精度质量保证,以便将实际给予的剂量与计划的剂量分布进行适形比较,并确保治疗质量。目前,这种控制大多通过电离室矩阵、二极管探测器、剂量测定胶片、射野成像或剂量测定凝胶来进行。另一种方法是闪烁剂量测定法,在过去15年中主要通过闪烁光纤装置得以发展。尽管与其他方法相比有许多优点,但由于照射时产生的切伦科夫辐射代表着一个重要的本底效应,它在常规剂量测定中仍处于实验阶段。在MAESTRO欧洲项目框架内,与卡昂的粒子物理实验室、弗朗索瓦·巴克莱斯综合癌症中心以及ELDIM公司合作,开发了一种新型二维水等效闪烁剂量计DosiMap和两种不同的切伦科夫鉴别方法。DosiMap由置于透明聚苯乙烯模体内部的塑料闪烁片组成。照射时产生的光分布由电荷耦合器件(CCD)相机记录。我们的第一种切伦科夫鉴别技术是减法技术。它使用置于闪烁体前方的棋盘图案,该图案提供仅包含切伦科夫光的背景信号。我们的第二种鉴别技术是比色法。它对光信号进行光谱分析,从而能够区分切伦科夫辐射和闪烁。使用我们的DosiMap原型进行了测试,并评估了两种鉴别方法的性能。对于三种不同的照射配置,用DosiMap和剂量测定胶片进行剂量测量的比较表明,在2毫米空间分辨率下,差异小于3.5%。展示了两种创新的鉴别方法来区分闪烁和切伦科夫辐射。还表明,水等效、快速且用户友好的DosiMap是放射治疗质量保证中非常有前景的工具。

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