Univ Lyon, Université Claude Bernard Lyon 1, CNRS, INSA Lyon, Ecole Centrale de Lyon, CPE Lyon, INL, UMR5270, Villeurbanne, France.
Univ. Grenoble Alpes, CNRS, Grenoble INP, TIMC, Grenoble, France.
Med Phys. 2023 Jan;50(1):619-632. doi: 10.1002/mp.15902. Epub 2022 Sep 2.
To develop a novel instrument for real-time quality assurance (QA) procedures in radiotherapy. The system implements a scintillation-based phantom and associated signal acquisition and processing modules and aims to monitor two-dimensional (2D) dose distributions of small fields.
For the proposed phantom, we have designed and realized a prototype implementing six high-resolution tissue-equivalent scintillating fiber ribbons stacked with in-plane 30° rotated orientations from each other. Each ribbon output is coupled to a silicon photodiode linear array (with an element pitch of 400 μm) to detect scintillating signal, which represents the projected irradiation profile perpendicular to the ribbon's orientation. For the system providing six acquired projected dose profiles at different orientations, we have developed a two-step signal processing method to perform 2D dose reconstruction. The first step is to determine irradiation field geometry parameters using a tomographic geometry approach, and the second one is to perform specific penumbra estimation. The QA system prototype has been tested on a Novalis TrueBeam STX with a 6-MV photon beam for small elliptic fields defined by 5- and 10-mm cone collimators and for 10 × 10- and 20 × 10-mm rectangular fields defined by the micro-multileaf collimator. Gamma index analysis using EBT3 films as reference has been carried out with tight 2%-dose-difference (DD)/700-μm-distance-to-agreement (DTA) as well as 1%-DD/1-mm-DTA criteria for evaluating the system performances. The testing also includes an evaluation of the proposed two-step field reconstruction method in comparison with two conventional methods: filtered back projection (FBP) and simultaneous iterative reconstruction technique (SIRT).
The reconstructed 2D dose distributions have gamma index pass rates higher than 95% for all the tested configurations as compared with EBT3 film measurements with both 2%-DD/700-μm-DTA and 1%-DD/1-mm criteria. 2D global gamma analysis shows that the two-step and FBP radiation field reconstruction methods systematically outperform the SIRT approach. Moreover, higher gamma index success rates are obtained with the two-step method than with FBP in the case of the fields defined with the stereotactic cones.
The proposed small-field QA system makes a use of six water-equivalent scintillating detectors (fiber ribbons) to acquire dose distribution. The developed two-step signal processing method performs tomographic 2D dose reconstruction. A system prototype has been built and tested using hospital facilities with small rectangular and elliptic fields. Testing results show 2D reconstructed dose distributions with high accuracy and resolution. Such a system could potentially be an alternative approach to film dosimetry for small-field QA, which is still widely used as reference in clinical practice.
开发一种用于放射治疗实时质量保证(QA)程序的新型仪器。该系统实现了基于闪烁体的体模以及相关的信号采集和处理模块,旨在监测小野的二维(2D)剂量分布。
对于所提出的体模,我们设计并实现了一个原型,其中包含六个高分辨率组织等效闪烁纤维带,彼此之间以平面内 30°的旋转方向堆叠。每个带的输出与硅光电二极管线性阵列(元素间距为 400μm)耦合,以检测代表与带取向垂直的照射轮廓的闪烁信号。对于提供六个在不同方向上采集的投影剂量分布的系统,我们开发了一种两步信号处理方法来进行 2D 剂量重建。第一步是使用层析成像几何方法确定照射野几何参数,第二步是进行特定的半影估计。QA 系统原型已在 Novalis TrueBeam STX 上使用 6MV 光子束进行了测试,用于测试由 5mm 和 10mm 锥形准直器定义的小椭圆形野,以及由微多叶准直器定义的 10×10mm 和 20×10mm 矩形野。使用 EBT3 胶片作为参考进行了伽马指数分析,使用严格的 2%-剂量差异(DD)/700μm-符合度(DTA)以及 1%-DD/1mm-DTA 标准来评估系统性能。测试还包括与两种传统方法(滤波反投影(FBP)和同时迭代重建技术(SIRT))相比,对所提出的两步场重建方法的评估。
与使用 2%-DD/700μm-DTA 和 1%-DD/1mm 标准的 EBT3 胶片测量相比,所有测试配置的重建 2D 剂量分布的伽马指数通过率均高于 95%。二维全局伽马分析表明,两步和 FBP 辐射场重建方法系统地优于 SIRT 方法。此外,在使用立体定向锥定义的野中,两步法比 FBP 获得更高的伽马指数成功率。
所提出的小野 QA 系统使用六个水等效闪烁探测器(纤维带)来获取剂量分布。开发的两步信号处理方法执行层析 2D 剂量重建。使用医院设施构建并测试了系统原型,其中包括小矩形和椭圆形野。测试结果表明,2D 重建剂量分布具有高精度和高分辨率。这种系统可能成为小野 QA 的胶片剂量学的替代方法,在临床实践中仍然广泛用作参考。