Department of Computer Science, Universiti Putra Malaysia, Selangor, Malaysia.
IET Nanobiotechnol. 2012 Sep;6(3):87-92. doi: 10.1049/iet-nbt.2011.0062.
Kinesin is a protein-based natural nanomotor that transports molecular cargoes within cells by walking along microtubules. Kinesin nanomotor is considered as a bio-nanoagent which is able to sense the cell through its sensors (i.e. its heads and tail), make the decision internally and perform actions on the cell through its actuator (i.e. its motor domain). The study maps the agent-based architectural model of internal decision-making process of kinesin nanomotor to a machine language using an automata algorithm. The applied automata algorithm receives the internal agent-based architectural model of kinesin nanomotor as a deterministic finite automaton (DFA) model and generates a regular machine language. The generated regular machine language was acceptable by the architectural DFA model of the nanomotor and also in good agreement with its natural behaviour. The internal agent-based architectural model of kinesin nanomotor indicates the degree of autonomy and intelligence of the nanomotor interactions with its cell. Thus, our developed regular machine language can model the degree of autonomy and intelligence of kinesin nanomotor interactions with its cell as a language. Modelling of internal architectures of autonomous and intelligent bio-nanosystems as machine languages can lay the foundation towards the concept of bio-nanoswarms and next phases of the bio-nanorobotic systems development.
肌球蛋白是一种基于蛋白质的天然纳米马达,它通过沿着微管行走来在细胞内运输分子货物。肌球蛋白纳米马达被认为是一种生物纳米剂,它能够通过其传感器(即头部和尾部)感知细胞,通过其执行器(即其马达域)在细胞内做出决策并采取行动。该研究使用自动机算法将肌球蛋白纳米马达的基于代理的内部决策过程的体系结构模型映射到机器语言。应用的自动机算法接收肌球蛋白纳米马达的基于代理的内部体系结构模型作为确定性有限自动机 (DFA) 模型,并生成正则机器语言。生成的正则机器语言被纳米马达的体系结构 DFA 模型接受,并且与它的自然行为也非常吻合。肌球蛋白纳米马达的基于代理的内部体系结构模型表明了纳米马达与细胞相互作用的自主性和智能程度。因此,我们开发的正则机器语言可以将肌球蛋白纳米马达与细胞相互作用的自主性和智能程度建模为一种语言。将自主和智能生物纳米系统的内部体系结构建模为机器语言,可以为生物纳米群和生物机器人系统下一阶段的发展奠定基础。