Macroporous/mesoporous bioglasses doped with Ag/TiO(2) for dual drug action property and bone repair.

A series of macroporous-mesoporous bioglasses (MMBGs) doped with Ag, TiO(2) and Ag/TiO(2) have been successfully prepared using the nature plants as the macroporous templates and P123 as the mesoporous one. The dual drug action (antifungus and anti-inflammatory) and bone regeneration systems have been obtained by Ibuprofen (Ibu) loaded. Meanwhile, the antifungus as well as drug control release profiles of these materials have been investigated. Compared with pure MMBGs, MMBGs-Ag, MMBGs-TiO(2) and MMBGs-Ag/TiO(2) showed much higher antimicrobial efficiency, faster hydroxyapatite-forming ability and better drug sustained release performance. The multifunctional hierarchical porous bioglasses materials may have potential applications in bone tissue engineering.