用于双药释放的分级多孔生物活性玻璃/聚乳酸-羟基乙酸共聚物-磁性SBA-15
Hierarchical porous bioactive glasses/PLGA-magnetic SBA-15 for dual-drug release.
作者信息
Ma Jie, Lin Huiming, Li Xiaofeng, Bian Chunhui, Xiang Di, Han Xiao, Wu Xiaodan, Qu Fengyu
机构信息
Key Laboratory of Design and Synthesis of Functional Materials and Green Catalysis, Harbin Normal University, Harbin 150025, PR China.
Key Laboratory of Design and Synthesis of Functional Materials and Green Catalysis, Harbin Normal University, Harbin 150025, PR China.
出版信息
Mater Sci Eng C Mater Biol Appl. 2014 Jun 1;39:21-8. doi: 10.1016/j.msec.2014.01.060. Epub 2014 Feb 10.
The hierarchical porous bioglass combined with magnetic SBA-15 was synthesized. The bioactive glass materials possess a hierarchical porous structure with the macroporous (50μm) and the mesoporous (3.86nm) structures derived from the plant template (cattail stem) and triblock polyethylene oxide-propylene oxide block copolymer (P123), respectively. Magnetic SBA-15 was synthesized by adopting the post assembly method using Fe(NO3)3 as iron source and ethylene glycol as reduction. After coating PLGA, PLGA-IBU-magnetic SBA-15 also possessed super-paramagnetism and the corresponding saturation magnetizations (Ms) could reach 2.6emug(-1). Metformin HCl (MH) and ibuprofen (IBU) were used as model drugs, and the drug release kinetics was studied. MH and IBU could release 60% and 85% from the sample respectively. The system shows excellent dual-drug controlled delivery performance and good bioactivity in vitro that leads to good potential application on bone regeneration.
合成了具有分级多孔结构的生物活性玻璃与磁性SBA - 15的复合材料。生物活性玻璃材料具有分级多孔结构，其中大孔（50μm）和介孔（3.86nm）结构分别源自植物模板（香蒲茎）和三嵌段聚环氧乙烷 - 环氧丙烷共聚物（P123）。以Fe(NO3)3为铁源、乙二醇为还原剂，采用后组装法合成了磁性SBA - 15。包覆PLGA后，PLGA - IBU - 磁性SBA - 15也具有超顺磁性，其相应的饱和磁化强度（Ms）可达2.6 emu g(-1)。以盐酸二甲双胍（MH）和布洛芬（IBU）为模型药物，研究了药物释放动力学。MH和IBU分别可从样品中释放60%和85%。该体系在体外表现出优异的双药控释性能和良好的生物活性，在骨再生方面具有良好的潜在应用前景。
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