Department of Chemistry, Shanghai University, Shanghai 200444, China.
Org Lett. 2012 Sep 7;14(17):4398-401. doi: 10.1021/ol3018775. Epub 2012 Aug 15.
An efficient palladium-catalyzed synthesis of N-functionalized multisubstituted indoles from easily accessible ortho-haloarylallenes and primary amines has been developed. A wide range of electronically and structurally varied nitrogen fragments could be introduced through this tandem C-N bond-forming process by tuning the reaction conditions.
一种高效的钯催化合成 N-官能化多取代吲哚的方法已经被开发出来，该方法从易得的邻卤芳基丙二烯和伯胺出发。通过调整反应条件，可以通过这种串联的 C-N 键形成过程引入广泛的电子和结构变化的氮片段。
