State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, P. R. China.
J Org Chem. 2012 Oct 19;77(20):9163-70. doi: 10.1021/jo301741j. Epub 2012 Sep 27.
A palladium-catalyzed tandem cyclization/C-H functionalization of two alkynes was accomplished to construct a series of polycyclic functionalized indoles. A range of internal alkynes bearing synthetically useful functional groups were tolerated. A good regioselectivity was observed when alkyl-substituted alkynes were introduced into the reaction system, and a single product was obtained. Molecular oxygen was used as the terminal oxidant in the approach, rendering the reaction more sustainable.
钯催化的串联环化/C-H 官能团化反应实现了两个炔烃的反应，构建了一系列多环官能化吲哚类化合物。一系列带有合成有用官能团的内部炔烃都可以被容忍。当在反应体系中引入取代烷基的炔烃时，观察到良好的区域选择性，得到单一产物。该方法中使用分子氧作为末端氧化剂，使反应更加可持续。
