Eckard Allison Ross, Judd Suzanne E, Ziegler Thomas R, Camacho-Gonzalez Andres F, Fitzpatrick Anne M, Hadley Graham R, Grossmann Ruth E, Seaton LaTeshia, Seydafkan Shabnam, Mulligan Mark J, Rimann Nayoka, Tangpricha Vin, McComsey Grace A
Emory University School of Medicine, Atlanta, GA, USA.
Antivir Ther. 2012;17(6):1069-78. doi: 10.3851/IMP2318. Epub 2012 Aug 16.
Vitamin D deficiency is common in HIV-infected individuals. In adults, traditional and HIV-related factors play a role in vitamin D status, and deficiency appears to impair immune restoration and exacerbate HIV complications, like cardiovascular disease (CVD). This study sought to determine factors contributing to vitamin D status in HIV-infected youth and investigate the relationship with CVD risk, inflammation and immune restoration.
HIV-infected subjects (1-25 years old) were enrolled prospectively along with healthy controls that were group-matched by age, sex and race. HIV data were collected for the HIV-infected group, while traditional risk factors, including vitamin D intake, sun exposure, skin pigmentation, physical activity level and body mass index (BMI) were collected for both groups. Fasting lipids, plasma 25-hydroxyvitamin D (25[OH]D), and inflammation markers were measured.
In total, 200 HIV-infected subjects and 50 controls were enrolled. HIV group had 53% male, 95% Black and a mean age of 17.2 ±4.6 years. There was no difference in 25(OH)D between groups; 77% of HIV+ and 74% of controls had 25(OH)D<20 ng/ml. Only Fitzpatrick skin type was independently associated with 25(OH)D. No HIV variables were associated with 25(OH)D, even when HIV sub-populations were examined. Inflammation, CVD risk factors and immune restoration were not independently associated with 25(OH)D.
Vitamin D deficiency is common among HIV-infected youth. However, HIV factors, CVD risk, inflammation and immune restoration do not appear to have the same relationship with vitamin D as has been shown in adults. Supplementation trials are needed to determine if increasing 25(OH)D concentrations could better elucidate these relationships.
维生素D缺乏在HIV感染者中很常见。在成年人中，传统因素和与HIV相关的因素对维生素D状态有影响，并且维生素D缺乏似乎会损害免疫恢复并加剧HIV相关并发症，如心血管疾病（CVD）。本研究旨在确定导致HIV感染青年维生素D状态的因素，并调查其与CVD风险、炎症和免疫恢复的关系。
前瞻性招募1至25岁的HIV感染受试者以及按年龄、性别和种族进行组匹配的健康对照。收集HIV感染组的HIV数据，同时收集两组的传统风险因素，包括维生素D摄入量、阳光暴露、皮肤色素沉着、身体活动水平和体重指数（BMI）。测量空腹血脂、血浆25-羟基维生素D（25[OH]D）和炎症标志物。
共招募了200名HIV感染受试者和50名对照。HIV组中男性占53%，黑人占95%，平均年龄为17.2±4.6岁。两组之间的25(OH)D无差异；77%的HIV感染者和74%的对照者25(OH)D<20 ng/ml。只有菲茨帕特里克皮肤类型与25(OH)D独立相关。即使对HIV亚组进行检查，也没有HIV变量与25(OH)D相关。炎症、CVD风险因素和免疫恢复与25(OH)D无独立相关性。
维生素D缺乏在HIV感染青年中很常见。然而，HIV因素、CVD风险、炎症和免疫恢复与维生素D的关系似乎与成年人中所显示的不同。需要进行补充试验来确定提高25(OH)D浓度是否能更好地阐明这些关系。
