Department of Pediatrics, UC Davis School of Medicine, Sacramento, CA, USA.
Gut Microbes. 2012 Nov-Dec;3(6):562-5. doi: 10.4161/gmic.21738. Epub 2012 Aug 16.
Necrotizing enterocolitis (NEC) is a common and devastating disease of premature infants. Immaturity of the innate immune system of the gut is central to the pathogenesis of NEC. Recent studies suggest a key role for Paneth cells in this disease. Addressing basic questions on the development and function of immature Paneth cells may shed light on the puzzling pathophysiology of NEC. Current animal models of NEC are limited in their capacity to answer these questions.
坏死性小肠结肠炎（NEC）是一种常见且严重的早产儿疾病。肠道先天免疫系统的不成熟是 NEC 发病机制的核心。最近的研究表明，潘氏细胞在这种疾病中起着关键作用。解决未成熟潘氏细胞发育和功能的基本问题可能有助于阐明 NEC 令人费解的病理生理学。目前 NEC 的动物模型在回答这些问题的能力上存在局限性。
