Department of Psychology, Queens College, City University of New York, Flushing, New York 11367, USA.
J Neurosci. 2012 Aug 15;32(33):11176-86. doi: 10.1523/JNEUROSCI.1172-12.2012.
Although possible sources and functions of the resting-state networks (RSNs) of the brain have been proposed, most evidence relies on circular logic and reverse inference. We propose that autonomic arousal provides an objective index of psychophysiological states during rest that may also function as a driving source of the activity and connectivity of RSNs. Recording blood oxygenation level-dependent (BOLD) signal using functional magnetic resonance imaging and skin conductance simultaneously during rest in human subjects, we found that the spontaneous fluctuations of BOLD signals in key nodes of RSNs are associated with changes in nonspecific skin conductance response, a sensitive psychophysiological index of autonomic arousal. Our findings provide evidence of an important role for the autonomic nervous system to the spontaneous activity of the brain during "rest."
尽管已经提出了大脑静息态网络（RSN）的可能来源和功能，但大多数证据依赖于循环逻辑和反向推理。我们提出，自主唤醒为休息时心理生理状态提供了一个客观指标，也可能作为 RSN 活动和连接的驱动源。在人类受试者休息期间同时使用功能磁共振成像和皮肤电导率记录血氧水平依赖（BOLD）信号，我们发现 RSN 关键节点的 BOLD 信号的自发波动与非特异性皮肤电导率反应的变化有关，这是非自主唤醒的敏感心理生理指标。我们的发现为自主神经系统在“休息”期间对大脑自发活动的重要作用提供了证据。
