Department of Neurology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire 03755-1404, USA.
J Neurosci. 2012 Aug 15;32(33):11365-76. doi: 10.1523/JNEUROSCI.1516-12.2012.
Status epilepticus (SE) is a common neurological emergency, which has been associated with subsequent cognitive impairments. Neuronal death in hippocampal CA1 is thought to be an important mechanism of these impairments. However, it is also possible that functional interactions between surviving neurons are important. In this study we recorded in vivo single-unit activity in the CA1 hippocampal region of rats while they performed a spatial memory task. From these data we constructed functional networks describing pyramidal cell interactions. To build the networks, we used maximum entropy algorithms previously applied only to in vitro data. We show that several months following SE pyramidal neurons display excessive neuronal synchrony and less neuronal reactivation during rest compared with those in healthy controls. Both effects predict rat performance in a spatial memory task. These results provide a physiological mechanism for SE-induced cognitive impairment and highlight the importance of the systems-level perspective in investigating spatial cognition.
癫痫持续状态（SE）是一种常见的神经系统急症，与随后的认知障碍有关。海马 CA1 区神经元死亡被认为是这些损伤的重要机制。然而，存活神经元之间的功能相互作用也可能很重要。在这项研究中，我们在大鼠进行空间记忆任务时记录了 CA1 海马区的体内单个神经元活动。根据这些数据，我们构建了描述锥体神经元相互作用的功能网络。为了构建网络，我们使用了先前仅应用于体外数据的最大熵算法。我们表明，与健康对照组相比，SE 后数月，锥体神经元在休息时表现出过度的神经元同步和较少的神经元再激活。这两种效应都可以预测大鼠在空间记忆任务中的表现。这些结果为 SE 引起的认知障碍提供了一种生理机制，并强调了在研究空间认知时从系统水平角度进行研究的重要性。
