作为颞叶癫痫认知障碍病因的θ节律病变
Theta Rhythmopathy as a Cause of Cognitive Disability in TLE.
作者信息
Shuman Tristan, Amendolara Benjamin, Golshani Peyman
机构信息
Departments of Neurology and Psychiatry, David Geffen School of Medicine, University of California Los Angeles (UCLA), Los Angeles, CA.
UCLA Medical Scientist Training Program, Los Angeles, CA.
出版信息
Epilepsy Curr. 2017 Mar-Apr;17(2):107-111. doi: 10.5698/1535-7511.17.2.107.
Abstract
Memory difficulties are commonly associated with temporal lobe epilepsy (TLE) and cause significant disability. This article reviews the role of altered hippocampal theta oscillations and theta-gamma coupling as potential causes of memory disturbance in temporal lobe epilepsy, dissecting the potential mechanisms underlying these changes in large-scale neuronal synchronization. We discuss development of treatments for cognitive dysfunction directed at restoring theta rhythmicity and future directions for research.
摘要
记忆障碍通常与颞叶癫痫（TLE）相关，并导致严重残疾。本文综述了海马θ振荡改变和θ-γ耦合作为颞叶癫痫记忆障碍潜在原因的作用，剖析了这些大规模神经元同步变化背后的潜在机制。我们讨论了针对恢复θ节律的认知功能障碍治疗方法的发展以及未来的研究方向。
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