Lee Jae-Min, Ji Eun-Sang, Kim Tae-Woon, Kim Chang-Ju, Shin Mal-Soon, Lim Baek-Vin, Chung Yong-Rak, Cho Young Sam
Department of Pharmacology, School of Medicine, The Catholic University of Korea, Seoul, Korea.
Department of Physiology, College of Medicine, Kyung Hee University, Seoul, Korea.
J Exerc Rehabil. 2018 Oct 31;14(5):713-723. doi: 10.12965/jer.36394.197. eCollection 2018 Oct.
Epilepsy is characterized by recurrent seizures and loss of neurons with abnormal rhythmic firing in the brains. In the present study, we investigated the effect of treadmill exercise on memory function in relation with cell proliferation and apoptosis in the hippocampus using pilocarpine-induced seizure rats. Epilepsy was initiated by intraperitoneal injection of pilocarpine hydrochloride. The rats in the exercise group were forced to run on a motorized treadmill for 30 min once a day for 2 weeks. In the present results, treadmill exercise alleviated short-term and spatial learning memory impairments in the epileptic rats. Treadmill exercise suppressed neuronal degeneration and enhanced neuronal maturation in the epileptic rats. Treadmill exercise suppressed cell proliferation and apoptosis in the epileptic rats. Treadmill exercise alleviated pilocarpine-induced memory impairments and suppressed neuronal loss in the hippocampus through down-regulation of apoptosis. These findings offer a possibility that treadmill exercise may provide a preventive or therapeutic value to the epilepsy-induced learning and memory impairments.
癫痫的特征是反复发作的癫痫发作以及大脑中神经元异常节律性放电并丧失。在本研究中，我们使用毛果芸香碱诱导的癫痫大鼠，研究了跑步机运动对记忆功能的影响以及与海马体中细胞增殖和凋亡的关系。通过腹腔注射盐酸毛果芸香碱引发癫痫。运动组的大鼠每天在电动跑步机上强迫跑步30分钟，持续2周。在目前的结果中，跑步机运动减轻了癫痫大鼠的短期和空间学习记忆障碍。跑步机运动抑制了癫痫大鼠的神经元变性并促进了神经元成熟。跑步机运动抑制了癫痫大鼠的细胞增殖和凋亡。跑步机运动通过下调凋亡减轻了毛果芸香碱诱导的记忆障碍并抑制了海马体中的神经元丢失。这些发现表明跑步机运动可能对癫痫引起的学习和记忆障碍具有预防或治疗价值。
