Section of Rheumatology, Instituto de Rehabilitación Psicofísica, Echeverría 955, 1428 Buenos Aires, Argentina.
Clin Rheumatol. 2012 Nov;31(11):1599-603. doi: 10.1007/s10067-012-2056-7. Epub 2012 Aug 16.
This study aimed to develop a simplified version of the Ankylosing Spondylitis Disease Activity Score (ASDAS). The study included consecutive patients with ankylosing spondylitis according to modified New York and/or Assessment in Ankylosing Spondylitis 2009 criteria. Sociodemographic data and characteristics of the disease (Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), Bath Ankylosing Spondylitis Functional Index (BASFI), and Ankylosing Spondylitis Quality of Life (ASQoL)) and erythrocyte sedimentation rate (ESR) were collected. ASDAS simplified version (SASDAS) was calculated as the simple linear sum of the five components of ASDAS which include: patient global assessment using visual analogue scale, back pain (BASDAI question no. 2), peripheral pain and swelling (BASDAI question no. 3), morning stiffness (BASDAI question no. 6), and ESR in millimeters per hour, divided by 10 so as to make it equivalent to the other scale's components. Eighty-six patients were included: 69 (80.2 %) were men with a median age of 46 years and median disease duration of 19 years. SASDAS showed an excellent correlation with the ASDAS (r = 0.93). SASDAS also showed a good correlation with night pain (r = 0.60), global pain (r = 0.69), ASQoL (r = 0.70), BASFI (r = 0.75), and BASDAI (r = 0.96). Using ASDAS cut-off values previously suggested, the corresponding cut-off values for SASDAS were as follows: from 0 to 7.8 (inactive disease), from 7.9 to 13.8 (moderate disease activity), from 13.9 to 27.6 (high disease activity), and above 27.6 (very high disease activity) with optimum sensitivity and specificity. SASDAS showed an excellent correlation with conventional clinical measures of disease activity, and it can be easily calculated and is simple to use in daily clinical practice.
本研究旨在开发简化版的强直性脊柱炎疾病活动评分（ASDAS）。该研究纳入了符合改良纽约和/或强直性脊柱炎 2009 年评估标准的连续强直性脊柱炎患者。收集了患者的社会人口统计学数据和疾病特征（Bath 强直性脊柱炎疾病活动指数（BASDAI）、Bath 强直性脊柱炎功能指数（BASFI）和强直性脊柱炎生活质量（ASQoL））和红细胞沉降率（ESR）。ASDAS 简化版（SASDAS）的计算方法是将 ASDAS 的五个组成部分的简单线性总和，包括：患者使用视觉模拟量表的总体评估、背痛（BASDAI 问题 2）、外周疼痛和肿胀（BASDAI 问题 3）、晨僵（BASDAI 问题 6）和毫米每小时的 ESR，除以 10，使其与其他量表的成分等效。共纳入 86 例患者：69 例（80.2%）为男性，中位年龄 46 岁，中位疾病病程 19 年。SASDAS 与 ASDAS 具有极好的相关性（r=0.93）。SASDAS 还与夜间疼痛（r=0.60）、整体疼痛（r=0.69）、ASQoL（r=0.70）、BASFI（r=0.75）和 BASDAI（r=0.96）具有良好的相关性。使用先前建议的 ASDAS 临界值，SASDAS 的相应临界值如下：0 至 7.8（无疾病活动），7.9 至 13.8（中度疾病活动），13.9 至 27.6（高度疾病活动）和 27.6 以上（极高疾病活动），具有最佳的敏感性和特异性。SASDAS 与疾病活动的常规临床指标具有极好的相关性，易于计算，在日常临床实践中使用简单。
