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氯仿增强疏水性金纳米晶体掺入二油酰基磷脂酰胆碱（DOPC）囊泡膜。

Chloroform-enhanced incorporation of hydrophobic gold nanocrystals into dioleoylphosphatidylcholine (DOPC) vesicle membranes.

机构信息

Department of Chemical Engineering, Texas Materials Institute, Center for Nano and Molecular Science and Technology, The University of Texas at Austin, Austin, Texas 78712-1062, United States.

出版信息

Langmuir. 2012 Sep 11;28(36):12971-81. doi: 10.1021/la302740j. Epub 2012 Aug 30.

DOI:10.1021/la302740j
PMID:22897240
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3510979/
Abstract

Vesicles of dioleoylphosphatidylcholine (DOPC) formed by extrusion (liposomes) with hydrophobic alkanethiol-capped Au nanocrystals were studied. Dodecanethiol-capped 1.8-nm-diameter Au nanocrystals accumulate in the lipid bilayer, but only when dried lipid-nanocrystal films were annealed with chloroform prior to hydration. Without chloroform annealing, the Au nanocrystals phase separate from DOPC and do not load into the liposomes. Au nanocrystals with slightly longer capping ligands of hexadecanethiol or with a larger diameter of 4.1 nm disrupted vesicle formation and created lipid assemblies with many internal lamellar attachments.

摘要

研究了由二油酰基磷脂酰胆碱 (DOPC) 形成的囊泡（脂质体），这些囊泡是通过挤出法（脂质体）与疏水烷硫醇封端的 Au 纳米晶形成的。十二硫醇封端的 1.8nm 直径的 Au 纳米晶在脂质双层中积累，但只有在干燥的脂质-纳米晶膜用氯仿退火后再水合时才会发生这种情况。如果没有氯仿退火，Au 纳米晶会与 DOPC 相分离，并且不会负载到脂质体中。具有稍长的封端配体十六硫醇或直径较大的 4.1nm 的 Au 纳米晶会破坏囊泡的形成，并产生具有许多内部层状附着的脂质组装体。

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本文引用的文献

[1]
Phospholipid vesicles as a model system for biomineralization.

Nature. 1986-12-11

[2]
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ACS Nano. 2012-6-4

[3]
Layer-by-layer assembly of thiol-capped au nanoparticles on a water surface and their deposition on H-terminated Si(001) by the Langmuir-Blodgett method.

Langmuir. 2011-3-3

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Nano Lett. 2011-2-25

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Doxorubicin loaded magnetic polymersomes: theranostic nanocarriers for MR imaging and magneto-chemotherapy.

ACS Nano. 2011-1-10

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Nanotoxicology. 2010-12-2

[10]
Hydrophobic gold nanoparticle self-assembly with phosphatidylcholine lipid: membrane-loaded and janus vesicles.

Nano Lett. 2010-9-8

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