Laboratory of Stem Cells and Cancer, The Hormel Institute, University of Minnesota, Austin, MN55912, USA.
Exp Dermatol. 2012 Sep;21(9):660-4. doi: 10.1111/j.1600-0625.2012.01566.x.
The skin provides an anatomical barrier to physical, chemical and biological agents. Hence, it is not surprising that it has well-developed innate immunity. What we find surprising is that the CD49f(+) /CD34(+) hair follicle stem cells should have an enriched expression profile of so many genes involved in innate immunity. Do these stem cells require extra protection from environmental insults? Or, could there be a new role for these genes? To probe these questions, we first summarize the roles of some key players in epidermal innate immunity. We next focus on their expression in CD49f(+) /CD34(+) hair follicle stem cells. Then, we consider recent data suggesting a new role for these 'old players' in the regulation and mobilization of haematopoietic and mesenchymal stem cells. Finally, we hypothesize that the 'old players' in these hair follicle stem cells may be playing a 'new game'.
皮肤为物理、化学和生物制剂提供了一个解剖学屏障。因此，它具有发达的先天免疫并不奇怪。令我们惊讶的是，CD49f(+) / CD34(+)毛囊干细胞应该具有如此多参与先天免疫的基因的丰富表达谱。这些干细胞是否需要额外的保护来免受环境的影响？或者，这些基因可能有新的作用？为了探究这些问题，我们首先总结了一些表皮先天免疫中关键分子的作用。接下来，我们重点关注它们在 CD49f(+) / CD34(+)毛囊干细胞中的表达。然后，我们考虑最近的数据表明，这些“旧的”分子在造血和间充质干细胞的调节和动员中可能具有新的作用。最后，我们假设这些毛囊干细胞中的“旧的”分子可能在发挥“新的作用”。
