磷脂转移蛋白 (PLTP) 对脂蛋白代谢的影响。
The impact of phospholipid transfer protein (PLTP) on lipoprotein metabolism.
机构信息
Department of Cell Biology, Downstate Medical Center, State University of New York, 450 Clarkson Ave,, Box 5, Brooklyn, NY, 11203, USA.
出版信息
Nutr Metab (Lond). 2012 Aug 16;9(1):75. doi: 10.1186/1743-7075-9-75.
Abstract
It has been reported that phospholipid transfer protein (PLTP) is an independent risk factor for human coronary artery disease. In mouse models, it has been demonstrated that PLTP overexpression induces atherosclerosis, while its deficiency reduces it. PLTP is considered a promising target for pharmacological intervention to treat atherosclerosis. However, we must still answer a number of questions before its pharmaceutical potential can be fully explored. In this review, we summarized the recent progresses made in the PLTP research field and focused on its effect on apoB-containing- triglyceride-rich particle and HDL metabolism.
摘要
据报道，磷脂转移蛋白 (PLTP) 是人类冠状动脉疾病的独立危险因素。在小鼠模型中，已经证明 PLTP 过表达会诱导动脉粥样硬化，而其缺乏则会减少动脉粥样硬化的发生。PLTP 被认为是治疗动脉粥样硬化的药物干预的一个有前途的靶点。然而，在充分探索其药物潜力之前，我们仍需回答许多问题。在这篇综述中，我们总结了 PLTP 研究领域的最新进展，并重点介绍了其对载 apoB 的甘油三酯丰富颗粒和 HDL 代谢的影响。
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