Laboratory of Neural Engineering, School of Biomedical Engineering/Research Center of Basic Medicine, Tianjin Medical University, Tianjin 300070, China.
Brain Res Bull. 2012 Nov 1;89(3-4):115-23. doi: 10.1016/j.brainresbull.2012.07.012. Epub 2012 Aug 7.
Cross-frequency coupling (CFC) between the theta (4-12Hz) phase and the amplitude of gamma (30-100Hz) oscillations occurs frequently in brain. However, the function of theta-gamma coupling in rat medial prefrontal cortex (mPFC) in working memory remains unclear. To address this issue, we studied 16-channel CFC in local field potentials (LFPs) recorded from the mPFC of over-trained rats as they performed a Y-maze working memory task. During this course, the amplitude of the low gamma subband (30-60Hz) was more strongly modulated by theta phase during the correct trials than in the error ones. Meanwhile, more channels showed higher theta-low gamma coupling levels during the correct performance. By contrast, the strength of theta-high gamma coupling did not significantly increase during the working memory task in both correct and error trials, indicating an insignificant correlation with the performance validity. These findings suggest a role of mPFC theta-low gamma coupling in working memory.
脑区间的θ（4-12Hz）相位与γ（30-100Hz）频段幅度的跨频耦合（CFC）较为常见。然而，在大鼠前额叶皮层（mPFC）中θ-γ耦合在工作记忆中的功能仍不清楚。为了解决这个问题，我们研究了在经过过度训练的大鼠执行 Y 型迷宫工作记忆任务时，mPFC 记录的 16 通道局部场电位（LFPs）中的 CFC。在此过程中，在正确试验中，与错误试验相比，θ 相位对低γ亚带（30-60Hz）的幅度调制更强。同时，在正确表现期间，更多的通道表现出更高的θ-低γ耦合水平。相比之下，在正确和错误试验中，θ-高γ耦合的强度在工作记忆任务中均未显著增加，表明与性能有效性无显著相关性。这些发现表明 mPFC 的θ-低γ耦合在工作记忆中起作用。
