Physiologisches Institut I, Systemic and Cellular Neurophysiology, Albert-Ludwigs-Universität Freiburg, Hermann-Herder-Straße 7, 79104 Freiburg, Germany.
Sci Rep. 2017 Mar 28;7:45508. doi: 10.1038/srep45508.
The medial prefrontal cortex (mPFC) integrates information from cortical and sub-cortical areas and contributes to the planning and initiation of behaviour. A potential mechanism for signal integration in the mPFC lies in the synchronization of neuronal discharges by theta (6-12 Hz) activity patterns. Here we show, using in vivo local field potential (LFP) and single-unit recordings from awake mice, that prominent oscillations in the sub-theta frequency band (1-5 Hz) emerge during awake immobility in the mPFC. These oscillation patterns are distinct from but phase-locked to hippocampal theta activity and occur synchronized with nasal respiration (hence termed prefrontal respiration rhythm [PRR]). PRR activity modulates the amplitude of prefrontal gamma rhythms with greater efficacy than theta oscillations. Furthermore, single-unit discharges of putative pyramidal cells and GABAergic interneurons are entrained by prefrontal PRR and nasal respiration. Our data thus suggest that PRR activity contributes to information processing in the prefrontal neuronal network.
内侧前额叶皮层（mPFC）整合来自皮质和皮质下区域的信息，并有助于行为的规划和启动。mPFC 中信号整合的一个潜在机制在于通过θ（6-12 Hz）活动模式来同步神经元放电。在这里，我们使用清醒小鼠的活体局部场电位（LFP）和单细胞记录显示，在 mPFC 清醒不动期间，亚 theta 频段（1-5 Hz）出现明显的振荡。这些振荡模式与海马 theta 活动不同但相位锁定，并与鼻呼吸同步（因此称为前额叶呼吸节律（PRR））。PRR 活动比 theta 振荡更有效地调节前额叶伽马节律的幅度。此外，假定的锥体神经元和 GABA 能中间神经元的放电被 PRR 和鼻呼吸所驱动。因此，我们的数据表明 PRR 活动有助于前额叶神经网络中的信息处理。
