急性 HIV-1 感染患者血浆中巨噬细胞移动抑制因子（MIF）水平升高。
Increased macrophage migration inhibitory factor (MIF) plasma levels in acute HIV-1 infection.
机构信息
Infectious Diseases Service, Department of Medicine, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland.
出版信息
Cytokine. 2012 Nov;60(2):338-40. doi: 10.1016/j.cyto.2012.07.027. Epub 2012 Aug 13.
Considering macrophage migratory inhibitory factor (MIF) as a critical pro-inflammatory cytokine of the immune system, we evaluated plasma MIF levels in 89 HIV-infected adults. Plasma MIF levels were higher in HIV-infected than in HIV-negative individuals. Highest MIF levels were observed during acute HIV infection (AHI) whilst patients on antiretroviral therapy (ART) had lower MIF levels, regardless of ART efficacy. Our results suggest that MIF is an integral component of the cytokine storm characteristic of AHI.
考虑到巨噬细胞移动抑制因子（MIF）是免疫系统中一种关键的促炎细胞因子，我们评估了 89 名 HIV 感染成年人的血浆 MIF 水平。HIV 感染患者的血浆 MIF 水平高于 HIV 阴性个体。在急性 HIV 感染（AHI）期间观察到最高的 MIF 水平，而接受抗逆转录病毒治疗（ART）的患者无论 ART 疗效如何，MIF 水平均较低。我们的结果表明，MIF 是 AHI 特征性细胞因子风暴的一个组成部分。
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