Sam-Wobo S O, Adeleke M A, Jayeola O A, Adeyi A O, Oluwole A S, Ikenga M, Lawniye F, Gazama J, Kagni A, Kosoko T O, Agbeyangi O, Bankole S, Toé L, Mafiana C F, Yameogo L
Department of Biological Sciences, University of Agriculture, Abeokuta, Nigeria.
J Vector Borne Dis. 2012 Jun;49(2):101-4.
BACKGROUND & OBJECTIVE: Epidemiological studies were carried out to assess the prevalence and community microfilarial load (CMFL) of onchocerciasis after repeated annual treatment with ivermectin along Ogun river System, southwest Nigeria.
Skin snips were taken from consented participants in 11 selected communities along the River system. The microfilarial load of the community was estimated.
The prevalence and CMFL varied significantly in the communities (p <0.05). The prevalence of onchocerciasis ranged from 19.1 to 45.6%, while the CMFL ranged from 0.11 to 1.03 microfilariae per skin snip. The CMFL recorded was <5 microfilariae per skin snip, i.e. recognized by WHO as threshold value in certifying the communities to be free of onchocerciasis as public health problem, thus, signifying the possibility of onchocerciasis elimination in the study area.
Efforts should therefore be intensified to achieve improved ivermectin coverage and compliance in annual ivermectin treatment in order to completely eliminate onchocerciasis as a public health problem in the studied communities.
开展流行病学研究，以评估在尼日利亚西南部奥贡河系统沿岸每年重复使用伊维菌素治疗后盘尾丝虫病的患病率和社区微丝蚴负荷（CMFL）。
从该河系沿线11个选定社区中同意参与的参与者身上采集皮肤切片。估算社区的微丝蚴负荷。
各社区的患病率和CMFL差异显著（p<0.05）。盘尾丝虫病的患病率在19.1%至45.6%之间，而CMFL在每片皮肤切片0.11至1.03条微丝蚴之间。记录的CMFL为每片皮肤切片<5条微丝蚴，即世界卫生组织认可的将社区认证为不存在作为公共卫生问题的盘尾丝虫病的阈值，因此，这表明在研究区域消除盘尾丝虫病具有可能性。
因此，应加大努力，提高伊维菌素的覆盖率，并在每年的伊维菌素治疗中提高依从性，以便在研究社区中完全消除作为公共卫生问题的盘尾丝虫病。
