Oyibo W A, Fagbenro-Beyioku A F
Department of Medical Microbiology and Parasitology, College of Medicine, University of Lagos, Idi-Araba, Nigeria.
East Afr Med J. 1997 May;74(5):326-30.
The effect of four years of cummulative annual treatment with ivermectin just before the fifth round of dosing with the drug was studied in six endemic communities where pretreatment data had been collected in 1992. Significant reductions in prevalence of microfilaridermics (PMF), skin microfilarial density (MFD) and community microfilarial load (CMFL) was recorded. Remarkable reductions in PMF were recorded in Gbodongi (53.0%), Ndanako (80.1%) and others. In all the communities, the infection was reduced to a hypo endemic status except for Gbodongi. This was corroborated by the increase in amicrofilaridermics. CMFL was reduced in Gbodongi by 64.2%, Lata (53.1%) and the least in Bongi (11.0%). Reduction in clinical manifestations were variable.
在1992年已收集治疗前数据的六个流行社区中，研究了在第五轮使用伊维菌素给药前连续四年每年使用该药物进行累积治疗的效果。记录到微丝蚴血症患病率（PMF）、皮肤微丝蚴密度（MFD）和社区微丝蚴负荷（CMFL）显著降低。在博东吉（53.0%）、恩达纳科（80.1%）等地记录到PMF显著降低。在所有社区中，除博东吉外，感染均降至低度流行状态。无微丝蚴血症者的增加证实了这一点。博东吉的CMFL降低了64.2%，拉塔降低了53.1%，邦吉降低最少，为11.0%。临床表现的减少各不相同。
