School of Agriculture, Royal Agricultural College, Cirencester, GL7 6JS Gloucestershire, United Kingdom.
Int J Hyg Environ Health. 2013 Jun;216(3):346-54. doi: 10.1016/j.ijheh.2012.07.005. Epub 2012 Aug 14.
From May to July 2011, one of the largest reported outbreaks of haemolytic uraemic syndrome (HUS) and bloody diarrhoea caused by the Shiga toxin-producing Escherichia coli (STEC) O104:H4 occurred in Germany and France. The hypothetical origin of the outbreak strain was a combined enteroaggregative E. coli and an enterohaemorrhagic E. coli with the ability to resist multi-antibiotics and produce Shiga-toxin 2. The combination of aggregative ability, antibiotic resistance and the production of Shiga-toxin 2 significantly affected the severity of the symptoms presented. Since humans may be the primary reservoir, it is likely that contamination could have occurred through contact with infected individuals. Farm food safety management, and hand hygiene training programmes are crucial to primary production to prevent or reduce risks of contamination.
2011 年 5 月至 7 月，德国和法国发生了最大规模的肠出血性大肠杆菌（STEC）O104：H4 引起的溶血性尿毒综合征（HUS）和血性腹泻爆发之一。爆发菌株的假设起源是一种具有聚集能力的产志贺毒素大肠杆菌和一种肠出血性大肠杆菌，具有抵抗多种抗生素和产生志贺毒素 2 的能力。聚集能力、抗生素耐药性和志贺毒素 2 的产生的结合显著影响了症状的严重程度。由于人类可能是主要的储存宿主，因此污染可能是通过与受感染个体接触而发生的。农场食品安全管理和手部卫生培训计划对初级生产至关重要，以防止或减少污染风险。
