Centre for Vision & Vascular Science, Queen's University of Belfast, Royal Victoria Hospital, Belfast, Antrim BT12 6BA, UK.
Eye (Lond). 2012 Oct;26(10):1357-62. doi: 10.1038/eye.2012.165. Epub 2012 Aug 17.
The aim of this study was to describe the prevalence and characteristics of drusen and pigmentary changes in a middle-aged population.
Retinal images from 500 individuals aged 18-54 years were included. The source of participants was two UK optometry practices. Retinal images were graded using the Wisconsin Age-Related Maculopathy Grading System. However, owing to the relatively young age of the population studied, a new category of drusen of smaller size (<31.5 μm) was introduced.
Drusen were identified within the central macular grid in 91.48% of all gradable eyes and in 444 subjects. Drusen sized <31.5 μm were present in 89.7% of eyes, drusen sized >31.5 μm and <63 μm were present in 45.9% of all eyes and drusen >63 μm and <125 μm were present in only 1.7% of eyes. No eye had drusen larger or equal to 125 μm. Very few eyes (1.2%) showed pigmentary changes within the grid. Drusen load increased with increasing age, P <0.001.
The frequency of drusen in a younger Caucasian population aged 18-54 years is high, with 91.48% of all gradable eyes having drusen. The most frequent drusen subtype was hard distinct drusen <31.5 μm. No druse greater or equal in size to 125 μm was seen. Pigmentary changes are rare.
本研究旨在描述中年人群中玻璃膜疣和色素变化的患病率和特征。
纳入了 500 名年龄在 18-54 岁的个体的视网膜图像。参与者的来源是两家英国验光诊所。使用威斯康星州年龄相关性黄斑变性分级系统对视网膜图像进行分级。然而，由于研究人群相对年轻，引入了一种新的较小尺寸（<31.5μm）的玻璃膜疣类别。
在所有可分级眼中，91.48%和 444 名受试者的中央黄斑网格中发现了玻璃膜疣。<31.5μm 大小的玻璃膜疣存在于 89.7%的眼中，>31.5μm 和 <63μm 大小的玻璃膜疣存在于所有眼中的 45.9%，而>63μm 和 <125μm 大小的玻璃膜疣仅存在于 1.7%的眼中。没有眼有等于或大于 125μm 的玻璃膜疣。网格内只有极少数眼（1.2%）出现色素变化。玻璃膜疣负荷随年龄增加而增加，P<0.001。
在年龄在 18-54 岁的年轻白种人群中，玻璃膜疣的发生率很高，所有可分级眼中有 91.48%存在玻璃膜疣。最常见的玻璃膜疣亚型是<31.5μm 的硬性明确玻璃膜疣。没有发现大小等于或大于 125μm 的玻璃膜疣。色素变化罕见。
