Moorfields Eye Hospital, London, United Kingdom.
Invest Ophthalmol Vis Sci. 2012 Sep 25;53(10):6568-75. doi: 10.1167/iovs.12-9756.
To evaluate the spatial distribution and total amount of macular pigment (MP) in patients with idiopathic macular telangiectasia type 2 (MacTel) compared to healthy subjects.
Totals of 53 MacTel patients and 38 normal subjects underwent macular pigment optical density (MPOD) measurement using a 2-wavelength autofluorescence (2-AF) technique. The peak MPOD and total MP (sum of pixel OD values) were measured within the central 21 degrees. Data were correlated with motion photometry in a cohort of normal subjects.
A Bland-Altman analysis revealed minimal differences between psychophysical and 2-AF measurements of MPOD (bias = 0.025, SD = 0.06, N = 156 values). In the normal comparison group, 2-AF MPOD peak had a median value of 0.57 (range 0.21-0.93), and median eccentricity of the peak was 0.19 degrees (range 0.00-0.41). In the MacTel group, MPOD peak had a median value of 0.08 (range 0.01-0.26), and median eccentricity of the peak was 5.04 degrees (range 0.18-7.27). The median total amount of MP within the central 21 degrees was greater for normal subjects (4802, range 2362-9215) than for the patients (2938, range 142-7198), but there was marked overlap between the groups. Comparison of the total amount within the central 8, 12, or 16 degrees to that within the central 21 degrees revealed underestimation of up to 68% (median 53%), 42% (27%), and 24% (8%), respectively.
Most MacTel patients have a normal total complement of MP with an abnormal paracentral distribution. The study highlights the limitations of MP measurement techniques that assume minimal MP at eccentricities less than 10.5 degrees.
评估特发性黄斑毛细血管扩张症 2 型（MacTel）患者与健康受试者相比，黄斑色素（MP）的空间分布和总量。
共有 53 名 MacTel 患者和 38 名正常受试者使用双波长自发荧光（2-AF）技术进行黄斑色素光密度（MPOD）测量。在中央 21 度范围内测量最大 MPOD 和总 MP（像素 OD 值之和）。在一组正常受试者中，将数据与运动光度法相关联。
Bland-Altman 分析显示 MPOD 的心理物理和 2-AF 测量之间差异极小（偏差=0.025，SD=0.06，N=156 个值）。在正常对照组中，2-AF MPOD 峰值的中位数为 0.57（范围 0.21-0.93），峰值的中位数偏心率为 0.19 度（范围 0.00-0.41）。在 MacTel 组中，MPOD 峰值的中位数为 0.08（范围 0.01-0.26），峰值的中位数偏心率为 5.04 度（范围 0.18-7.27）。中央 21 度内的 MP 总量中位数在正常受试者中较大（4802，范围 2362-9215），而在患者中较小（2938，范围 142-7198），但两组之间存在明显重叠。与中央 21 度内的总量相比，中央 8、12 或 16 度内的总量分别低估了多达 68%（中位数 53%）、42%（27%）和 24%（8%）。
大多数 MacTel 患者的总 MP 含量正常，但旁中心分布异常。该研究强调了假设小于 10.5 度的偏心度处的 MP 最小的 MP 测量技术的局限性。
