Navarro X, Kennedy W R
Department of Cell Biology and Physiology, Universitat Autònoma de Barcelona, Bellaterra, Spain.
J Auton Nerv Syst. 1990 Nov;31(2):101-7. doi: 10.1016/0165-1838(90)90066-r.
This study evaluates sudomotor function in the hindpaw of young and aged mice. Sweating was stimulated by pilocarpine injection and by electrical stimulation of the sciatic, tibial, peroneal, sural and saphenous nerves. The number of responsive sweat glands of the paw was determined by the silicon mold technique. The results obtained provide evidence that the number of functioning sweat glands of the hindpaw tended to decrease in aged mice. The peripheral sudomotor territories and the complement of sweat glands for individual nerves declined slightly with age. Moreover, the number of sweat glands responsive to cholinergic stimulation was decreased when compared with the number responsive to electrical stimulation of the sciatic nerve in aged mice. These and previous observations suggest that the number of sudomotor axons in the peripheral nerve, as well as their capabilities for compensatory reinnervation of sweat glands by regeneration and by sprouting, is reduced with aging.
本研究评估了年轻和老年小鼠后爪的汗腺运动功能。通过注射毛果芸香碱以及电刺激坐骨神经、胫神经、腓总神经、腓肠神经和隐神经来刺激出汗。采用硅模技术确定爪部有反应的汗腺数量。所得结果表明，老年小鼠后爪中功能正常的汗腺数量有减少的趋势。随着年龄增长，外周汗腺运动区域以及各条神经的汗腺补充略有下降。此外，与老年小鼠中对坐骨神经电刺激有反应的汗腺数量相比，对胆碱能刺激有反应的汗腺数量减少。这些以及之前的观察结果表明，随着年龄增长，外周神经中汗腺运动轴突的数量及其通过再生和出芽对汗腺进行代偿性再支配的能力会降低。
