Kennedy W R, Sakuta M, Quick D C
Neuroscience. 1984 Mar;11(3):741-9. doi: 10.1016/0306-4522(84)90057-5.
The sweat territories of peripheral nerves to the hind-paw of the mouse were defined by a silastic impression mold method that allowed identification of every secreting sweat gland. It was found that the tibial, sural, saphenous and peroneal nerves all contribute to the innervation of foot pad sweat glands, and there is extensive overlapping of the sweat territories of the different peripheral nerves. Most sweat glands could be activated by electrical stimulation of axons in two or three peripheral nerves or in separate fascicles of one nerve. This was interpreted to indicate that these sweat glands receive multiple innervation and that sweat glands in the overlap regions between autonomous zones of adjacent cutaneous nerves can receive axons from each nerve. Partial denervation of sweat glands by section of one source of innervation did not prevent the gland from sweating during stimulation of intact axons to the gland, or after pilocarpine treatment. Totally denervated glands did not exhibit denervation hypersensitivity; they became unresponsive to pilocarpine, acetylcholine and adrenaline. These characteristics allowed detection of the appearance and progression of reinnervation (and reactivation) of denervated sweat glands by collateral branching from sudomotor fibers. Not only do these results increase our basic understanding of the anatomical relations between peripheral nerves and the sweat glands they innervate, but they also demonstrate that the mouse sweat gland provides a useful model system for studying neuropathology of the sympathetic nervous system.
通过硅橡胶印模法确定了小鼠后爪外周神经的汗腺分布区域，该方法能够识别每一个分泌汗腺。研究发现，胫神经、腓肠神经、隐神经和腓总神经均参与足垫汗腺的神经支配，不同外周神经的汗腺分布区域存在广泛重叠。大多数汗腺可通过电刺激两条或三条外周神经的轴突或一条神经的不同束支来激活。这被解释为表明这些汗腺接受多重神经支配，并且相邻皮神经自主区重叠区域的汗腺可从每条神经接收轴突。切断一条神经支配来源对汗腺进行部分去神经支配，并不妨碍在刺激支配该汗腺的完整轴突时或毛果芸香碱处理后汗腺出汗。完全去神经支配的汗腺未表现出去神经超敏反应；它们对毛果芸香碱、乙酰胆碱和肾上腺素无反应。这些特征使得能够检测去神经支配汗腺通过发汗运动纤维的侧支分支进行再支配（和再激活）的出现和进展情况。这些结果不仅增进了我们对外周神经与其所支配汗腺之间解剖关系的基本理解，还表明小鼠汗腺为研究交感神经系统神经病理学提供了一个有用的模型系统。
