茯苓酸通过PITPNM3抑制乳腺癌转移

Inhibition of breast cancer metastasis via PITPNM3 by pachymic acid.

作者信息

Hong Ri, Shen Min-He, Xie Xiao-Hong, Ruan Shan-Ming

机构信息

Department of Breast, the First School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, China.

出版信息

Asian Pac J Cancer Prev. 2012;13(5):1877-80. doi: 10.7314/apjcp.2012.13.5.1877.

DOI:10.7314/apjcp.2012.13.5.1877

PMID:22901140

Abstract

Breast cancer metastasis is the most common cause of cancer-related death in women. Thus, seeking targets of breast tumor cells is an attractive goal towards improving clinical treatment. The present study showed that CCL18 from tumor-associated macrophages could promote breast cancer metastasis via PITPNM3. In addition, we found that pachymic acid (PA) could dose-dependently inhibit migration and invasion of MDA-MB-231 cells, with or without rCCL18 stimulation. Furthermore, evidence was obtained that PA could suppress the phosphorylation of PITPNM3 and the combination of CCL18 and PITPNM3. Therefore, we speculate that PA could inhibit breast cancer metastasis via PITPNM3.

摘要

乳腺癌转移是女性癌症相关死亡的最常见原因。因此，寻找乳腺肿瘤细胞的靶点是改善临床治疗的一个有吸引力的目标。本研究表明，肿瘤相关巨噬细胞分泌的CCL18可通过PITPNM3促进乳腺癌转移。此外，我们发现茯苓酸（PA）可剂量依赖性地抑制MDA-MB-231细胞的迁移和侵袭，无论有无rCCL18刺激。此外，有证据表明PA可抑制PITPNM3的磷酸化以及CCL18与PITPNM3的结合。因此，我们推测PA可能通过PITPNM3抑制乳腺癌转移。