Division of Hematology, University Hospital Zurich, Zurich, Switzerland.
Ann N Y Acad Sci. 2012 Aug;1266:40-6. doi: 10.1111/j.1749-6632.2012.06500.x.
Hematopoietic stem cell (HSC) division leads to self-renewal, differentiation, or death of HSCs, and adequate balance of this process results in sustained, lifelong, high-throughput hematopoiesis. Despite their contribution to hematopoietic cell production, the majority of cells within the HSC population are quiescent at any given time. Recent studies have tackled the questions of how often HSCs divide, how divisional history relates to repopulating potential, and how many HSCs contribute to hematopoiesis. Here, we summarize these recent findings on HSC turnover from different experimental systems and discuss hypothetical models for HSC cycling and maintenance in steady-state and upon hematopoietic challenge.
造血干细胞（HSC）的分裂会导致 HSC 的自我更新、分化或死亡，而这个过程的充分平衡会导致持续的、终身的、高通量的造血。尽管它们对造血细胞的产生有贡献，但在任何给定的时间，HSC 群体中的大多数细胞都处于静止状态。最近的研究解决了 HSCs 分裂的频率、分裂历史与再殖潜能的关系以及有多少 HSCs 对造血的贡献等问题。在这里，我们总结了来自不同实验系统的关于 HSC 周转率的这些最新发现，并讨论了在稳态和造血挑战下 HSC 循环和维持的假设模型。
