• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

CYP1A2-163C>A 多态性与巴西精神分裂症患者氯氮平诱导的全面性强直-阵挛发作有关。

The CYP1A2 -163C>A polymorphism is associated with clozapine-induced generalized tonic-clonic seizures in Brazilian schizophrenia patients.

机构信息

Departamento de Biologia Geral, Universidade Federal Fluminense, Niterói, Brazil.

出版信息

Psychiatry Res. 2013 Sep 30;209(2):242-5. doi: 10.1016/j.psychres.2013.02.030. Epub 2013 Apr 18.

DOI:10.1016/j.psychres.2013.02.030
PMID:23601795
Abstract

We evaluated two polymorphisms at CYP1A2 (*1C and *1F) in a sample of 108 European-derived patients with schizophrenia and their influence on the pro-convulsive effect of clozapine. We found the *1F/*1F genotype to be significantly associated with seizures, and no relationship was observed with combinations of *1F and *1C alleles.

摘要

我们评估了 CYP1A2 （1C 和 1F）的两个多态性在 108 例欧洲裔精神分裂症患者样本中的作用及其对氯氮平致惊厥作用的影响。我们发现1F/1F 基因型与癫痫发作显著相关，而1F 和1C 等位基因的组合与癫痫发作无关系。

相似文献

1
The CYP1A2 -163C>A polymorphism is associated with clozapine-induced generalized tonic-clonic seizures in Brazilian schizophrenia patients.CYP1A2-163C>A 多态性与巴西精神分裂症患者氯氮平诱导的全面性强直-阵挛发作有关。
Psychiatry Res. 2013 Sep 30;209(2):242-5. doi: 10.1016/j.psychres.2013.02.030. Epub 2013 Apr 18.
2
Association between CYP1A2 polymorphisms and clozapine-induced adverse reactions in patients with schizophrenia.CYP1A2 多态性与精神分裂症患者氯氮平所致不良反应的相关性。
Psychiatry Res. 2012 Dec 30;200(2-3):1014-7. doi: 10.1016/j.psychres.2012.07.002. Epub 2012 Aug 16.
3
CYP1A2*1D and *1F polymorphisms have a significant impact on olanzapine serum concentrations.CYP1A2*1D和*1F基因多态性对奥氮平的血清浓度有显著影响。
Ther Drug Monit. 2015 Apr;37(2):152-60. doi: 10.1097/FTD.0000000000000119.
4
Cytochrome P450 1A2 co-determines neuroleptic load and may diminish tardive dyskinesia by increased inducibility.细胞色素P450 1A2共同决定抗精神病药物负荷，并可能通过增加诱导性来减轻迟发性运动障碍。
World J Biol Psychiatry. 2015 Apr;16(3):200-5. doi: 10.3109/15622975.2014.995222. Epub 2015 Jan 20.
5
The cytochrome P450 CYP1A2 genetic polymorphisms *1F and *1D do not affect clozapine clearance in a group of schizophrenic patients.细胞色素P450 CYP1A2基因多态性*1F和*1D不影响一组精神分裂症患者的氯氮平清除率。
Ann Clin Biochem. 2005 May;42(Pt 3):216-9. doi: 10.1258/0004563053857798.
6
Development of asymptomatic pancreatitis with paradoxically high serum clozapine levels in a patient with schizophrenia and the CYP1A2*1F/1F genotype.一名患有精神分裂症且具有CYP1A2*1F/1F基因型的患者出现无症状性胰腺炎，同时血清氯氮平水平反常升高。
J Clin Psychopharmacol. 2010 Dec;30(6):737-9. doi: 10.1097/JCP.0b013e3181faa7e3.
7
Clinical and genetic influencing factors on clozapine pharmacokinetics in Tunisian schizophrenic patients.影响氯氮平在突尼斯精神分裂症患者药代动力学的临床和遗传因素。
Pharmacogenomics J. 2021 Oct;21(5):551-558. doi: 10.1038/s41397-021-00231-x. Epub 2021 Mar 17.
8
Seizure on low-dose clozapine.低剂量氯氮平引发的癫痫发作。
Can J Psychiatry. 1998 May;43(4):420.
9
Drug-induced speech dysfluency and myoclonus preceding generalized tonic-clonic seizures in an adolescent male with schizophrenia.一名患有精神分裂症的青少年男性在全身性强直阵挛发作前出现药物诱发的言语不流畅和肌阵挛。
J Child Adolesc Psychopharmacol. 2010 Jun;20(3):233-4. doi: 10.1089/cap.2009.0010.
10
CYP1A2 polymorphism -1545C > T (rs2470890) is associated with increased side effects to clozapine.CYP1A2 多态性-1545C > T(rs2470890)与氯氮平不良反应增加有关。
BMC Psychiatry. 2014 Feb 20;14:50. doi: 10.1186/1471-244X-14-50.

引用本文的文献

1
Impact of Pharmacogenetic Testing on Clozapine Treatment Efficacy in Patients with Treatment-Resistant Schizophrenia.药物基因检测对难治性精神分裂症患者氯氮平治疗疗效的影响
Biomedicines. 2024 Mar 7;12(3):597. doi: 10.3390/biomedicines12030597.
2
Cross-Disorder Genomics Data Analysis Elucidates a Shared Genetic Basis Between Major Depression and Osteoarthritis Pain.跨疾病基因组数据分析揭示了重度抑郁症与骨关节炎疼痛之间的共同遗传基础。
Front Genet. 2021 Sep 16;12:687687. doi: 10.3389/fgene.2021.687687. eCollection 2021.
3
Pharmacogenomics of Cognitive Dysfunction and Neuropsychiatric Disorders in Dementia.
痴呆认知功能障碍和神经精神障碍的药物基因组学。
Int J Mol Sci. 2020 Apr 26;21(9):3059. doi: 10.3390/ijms21093059.
4
PharmGKB summary: clozapine pathway, pharmacokinetics.药物基因组知识库总结：氯氮平途径，药代动力学。
Pharmacogenet Genomics. 2018 Sep;28(9):214-222. doi: 10.1097/FPC.0000000000000347.
5
The effect of gene polymorphism on the metabolism of theophylline.基因多态性对茶碱代谢的影响。
Exp Ther Med. 2018 Jan;15(1):109-114. doi: 10.3892/etm.2017.5396. Epub 2017 Oct 30.
6
Seizure associated with clozapine: incidence, etiology, and management.氯氮平相关癫痫发作：发病率、病因及管理
CNS Drugs. 2015 Feb;29(2):101-11. doi: 10.1007/s40263-014-0222-y.
7
CYP1A2 polymorphism -1545C > T (rs2470890) is associated with increased side effects to clozapine.CYP1A2 多态性-1545C > T(rs2470890)与氯氮平不良反应增加有关。
BMC Psychiatry. 2014 Feb 20;14:50. doi: 10.1186/1471-244X-14-50.