CYP1A2-163C>A 多态性与巴西精神分裂症患者氯氮平诱导的全面性强直-阵挛发作有关。
The CYP1A2 -163C>A polymorphism is associated with clozapine-induced generalized tonic-clonic seizures in Brazilian schizophrenia patients.
机构信息
Departamento de Biologia Geral, Universidade Federal Fluminense, Niterói, Brazil.
出版信息
Psychiatry Res. 2013 Sep 30;209(2):242-5. doi: 10.1016/j.psychres.2013.02.030. Epub 2013 Apr 18.
Abstract
We evaluated two polymorphisms at CYP1A2 (*1C and *1F) in a sample of 108 European-derived patients with schizophrenia and their influence on the pro-convulsive effect of clozapine. We found the *1F/*1F genotype to be significantly associated with seizures, and no relationship was observed with combinations of *1F and *1C alleles.
摘要
我们评估了 CYP1A2 （1C 和 1F）的两个多态性在 108 例欧洲裔精神分裂症患者样本中的作用及其对氯氮平致惊厥作用的影响。我们发现1F/1F 基因型与癫痫发作显著相关，而1F 和1C 等位基因的组合与癫痫发作无关系。
Zotero 插件