Department of Clinical Oral Oncology, Unit of Translational Medicine, Nagasaki University Graduate School of Biomedical Sciences, Japan.
Int J Oral Maxillofac Surg. 2012 Oct;41(10):1195-200. doi: 10.1016/j.ijom.2012.07.011. Epub 2012 Aug 14.
Local recurrence of oral squamous cell carcinoma (OSCC) after primary surgery has been considered to be a poor prognostic entity in terms of survival rate. The purpose of this study is to evaluate the incidence of local recurrence and to identify significant risk factors for the local recurrence in OSCC. The authors retrospectively reviewed records for 187 patients who underwent radical surgery for OSCC. The local recurrence rate was 16.0% (30/187 patients) in this study. The survival rate of patients with local recurrence was 33.3%, which was significantly lower than that (94.3%) of patients without local recurrence. Pattern of invasion (POI), neoadjuvant chemotherapy (NAC), and the status of the surgical margin were identified as factors influencing local recurrence. In particular, NAC and the status of the surgical margin were independent risk factors by multivariate analysis. The deep margin was resected at a close site in many NAC-treated patients, suggesting that NAC may lead to local recurrence and poor outcomes. No efficacy of NAC was observed, suggesting that the standard treatment of oral cancers is surgery alone.
口腔鳞状细胞癌（OSCC）术后局部复发的生存率被认为是预后不良的实体。本研究旨在评估局部复发的发生率，并确定 OSCC 局部复发的显著危险因素。作者回顾性分析了 187 例接受 OSCC 根治性手术的患者的记录。本研究中局部复发率为 16.0%（30/187 例）。局部复发患者的生存率为 33.3%，明显低于无局部复发患者（94.3%）。浸润模式（POI）、新辅助化疗（NAC）和手术切缘状态被确定为影响局部复发的因素。特别是，多因素分析显示 NAC 和手术切缘状态是独立的危险因素。在许多接受 NAC 治疗的患者中，深切缘在靠近部位被切除，这表明 NAC 可能导致局部复发和不良预后。未观察到 NAC 的疗效，这表明口腔癌的标准治疗是单独手术。
