Ustad Mohammed Tasveem, Siddiqa Aaisha, Hallur Neelakamal H, Zakaullah Syed, Kothari Chaitanya, Fatima Shereen, Kudchi Najmussahar, Hussain Syed Manazir
Department of Oral and Maxillofacial Surgery, Al-Badar Rural Dental College and Hospital, Naganhalli Road, Kalaburagi, Karnataka India.
Department of Pathology, ESIC Medical and Hospital Kalaburagi, Kalaburagi, Karnataka India.
J Maxillofac Oral Surg. 2025 Feb;24(1):200-206. doi: 10.1007/s12663-024-02425-9. Epub 2025 Jan 7.
Sentinel lymph node is the first lymph node to drain a metastatic tumor cell or cluster of cells that drains via the lymphatic route. Mapping from the tumor site to the regional lymphatic drainage area can be used to identify the primary draining lymph node. The status of the sentinel node decides the need for neck dissection. The purpose of this study is to evaluate the efficacy of in identification of in oral squamous cell carcinoma. A total of 10 patients diagnosed histopathologically with oral squamous cell carcinoma were included in the study. Efficacy of methylene blue intraoperatively as an injectable medium for sentinel lymph node biopsy is established.
SLN were identified in all the 10 cases, with an average of 1.8 SLN per patient and standard deviation of 1.13.
We conclude that, methylene blue is an effective, hypoallergenic, low cost and easily available dye that has shown promising results in identification of sentinel lymph nodes in early oral cancer, signifying the important role to be played by SLNB procedures in deciding the type of neck dissection with least morbidity and maximum outcome.
前哨淋巴结是首个引流经淋巴途径转移的肿瘤细胞或细胞簇的淋巴结。从肿瘤部位到区域淋巴引流区的映射可用于识别主要引流淋巴结。前哨淋巴结的状态决定了是否需要进行颈部清扫术。本研究的目的是评估[具体内容缺失]在口腔鳞状细胞癌中识别[具体内容缺失]的疗效。本研究共纳入10例经组织病理学诊断为口腔鳞状细胞癌的患者。术中使用亚甲蓝作为前哨淋巴结活检的注射介质的疗效得到了证实。
10例患者均识别出前哨淋巴结，平均每位患者有1.8个前哨淋巴结，标准差为1.13。
我们得出结论，亚甲蓝是一种有效、低致敏性、低成本且易于获得的染料，在早期口腔癌前哨淋巴结的识别中显示出有前景的结果，这表明前哨淋巴结活检程序在决定颈部清扫术类型方面发挥着重要作用，可使发病率最低且效果最佳。
