Discipline of Oral and Maxillofacial Surgery, Faculty of Dentistry, University of Hong Kong, Hong Kong SAR, China.
Oral Surg Oral Med Oral Pathol Oral Radiol. 2012 Dec;114(6):698-703. doi: 10.1016/j.oooo.2012.01.041. Epub 2012 Aug 15.
The study aimed to evaluate the expression of MMP-1 and TIMP-1 in irradiated mandibles during distraction osteogenesis.
Rabbits in the experimental group received preoperative radiation of 9 Gy for 5 fractions. After 1 month, all rabbits underwent osteotomy and distraction osteogenesis with 7 days of latency. Three rabbits in the control and experimental groups were killed at days 7, 12, 18, and 25. Specimens were subjected to immunohistochemical examination and real-time polymerase chain reaction analysis.
At day 7, expression of MMP-1 and TIMP-1 was significantly suppressed in the radiotherapy group in contrast to the control group. At day 12, expression of MMP-1 was significantly higher in the control group. At day 18, expression of MMP-1 and TIMP-1 was significantly higher in the control than in the radiotherapy group.
Radiotherapy changes the expression pattern of MMP-1 and TIMP-1.
本研究旨在评估 MMP-1 和 TIMP-1 在放射性下颌骨牵张成骨过程中的表达。
实验组兔子接受术前 9 Gy 5 次分割照射。1 个月后，所有兔子均行骨切开术和牵张成骨术，潜伏期 7 天。对照组和实验组各有 3 只兔子分别于第 7、12、18 和 25 天处死。对标本进行免疫组织化学检查和实时聚合酶链反应分析。
与对照组相比，放疗组 MMP-1 和 TIMP-1 的表达在第 7 天显著受到抑制。第 12 天，对照组 MMP-1 的表达明显升高。第 18 天，对照组 MMP-1 和 TIMP-1 的表达明显高于放疗组。
放疗改变了 MMP-1 和 TIMP-1 的表达模式。
