Department of Medical Science, Psychiatry Unit, University of Foggia, Italy.
Psychiatry Res. 2012 Jul 30;203(1):54-60. doi: 10.1016/j.pscychresns.2012.02.008. Epub 2012 Aug 15.
Earlier neuroimaging studies of motor function in schizophrenia have demonstrated reduced functional lateralization in the motor network during motor tasks. Here, we used event-related functional magnetic resonance imaging during a visually guided motor task in 18 clinically unaffected siblings of patients with schizophrenia and 24 matched controls to investigate if abnormal functional lateralization is related to genetic risk for this brain disorder. Whereas activity associated with motor task performance was mainly contralateral with only a marginal ipsilateral component in healthy participants, unaffected siblings had strong bilateral activity with significantly greater response in ipsilateral and contralateral premotor areas as well as in contralateral subcortical motor regions relative to controls. Reduced lateralization in siblings was also identified with a measure of laterality quotient. These findings suggest that abnormal functional lateralization of motor circuitry is related to genetic risk of schizophrenia.
早期关于精神分裂症运动功能的神经影像学研究表明，在运动任务中运动网络的功能侧化减少。在这里，我们在 18 名精神分裂症患者的临床无影响兄弟姐妹和 24 名匹配的对照者中，使用与事件相关的功能磁共振成像，在视觉引导的运动任务中，研究异常的功能侧化是否与这种大脑障碍的遗传风险有关。虽然与运动任务表现相关的活动主要是对侧的，只有边缘的同侧成分在健康参与者中，但无影响的兄弟姐妹有强烈的双侧活动，同侧和对侧运动前区以及对侧皮质下运动区的反应明显更大，与对照组相比。用侧化商的测量也发现了兄弟姐妹的侧化减少。这些发现表明，运动回路的异常功能侧化与精神分裂症的遗传风险有关。
