Colette S, Donnez J
Pôle de recherche en gynécologie, département de gynécologie, université catholique de Louvain, institut de recherche expérimentale et clinique, cliniques universitaires Saint-Luc, avenue Hippocrate 10, 1200 Bruxelles, Belgique.
Gynecol Obstet Fertil. 2012 Sep;40(9):494-6. doi: 10.1016/j.gyobfe.2012.07.009. Epub 2012 Aug 15.
Sampson's menstrual reflux theory is commonly used to explain the origin of endometriotic lesions in women. However, their pathogenesis remains largely unknown. Validated research models need to be developed with the aim of studying mechanisms by which endometrial cells from menstrual reflux implant and grow, and investigating if potential new markers or molecules could be envisaged as diagnostic or therapeutic tools. The present review looks at the different existing murine and non-human primate models of endometriosis, and evaluates their principal uses.
桑普森的月经逆流理论常用于解释女性子宫内膜异位症病灶的起源。然而,其发病机制在很大程度上仍不清楚。需要开发经过验证的研究模型,目的是研究月经逆流中的子宫内膜细胞植入和生长的机制,并研究是否可以设想潜在的新标志物或分子作为诊断或治疗工具。本综述探讨了现有的不同的子宫内膜异位症小鼠和非人类灵长类动物模型,并评估了它们的主要用途。