Department of Medicine, University of Washington, Seattle, WA 98195, USA.
Cell. 2012 Aug 17;150(4):667-8. doi: 10.1016/j.cell.2012.07.027.
There has not been a new reversible contraceptive for men since the development of the condom, centuries ago. Matzuk et al. describe a new molecular approach using administration of a small molecule to directly and reversibly inhibit spermatogenesis in mice by blocking the function of a testicular bromodomain without apparent adverse effect on the organism or offspring.
自几个世纪前避孕套问世以来，男性一直没有新的可逆避孕方法。Matzuk 等人描述了一种新的分子方法，即通过使用一种小分子直接和可逆地抑制精子发生，从而阻断睾丸溴结构域的功能，而对机体或后代没有明显的不良影响。
