School of Chemical Sciences and Food Technology, Faculty of Science and Technology, 43600 Universiti Kebangsaan Malaysia, Selangor, Malaysia.
Bioorg Med Chem Lett. 2012 Sep 15;22(18):5780-3. doi: 10.1016/j.bmcl.2012.07.101. Epub 2012 Aug 4.
Variation at the 3' position of fluorescein via Suzuki-Miyaura cross-coupling with aryl and heteroaryl moieties gave a family of anthofluoresceins whose spectroscopic properties were studied. The 1-methylindole derivative gave the highest quantum yield and was observed to behave as a molecular rotor, displaying marked variations in fluorescent intensities with viscosity and offering possible application in cellular sensing and fluorescent polarisation assays.
通过与芳基和杂芳基的 Suzuki-Miyaura 交叉偶联，在荧光素的 3' 位发生变化，得到了一系列的蒽荧光素，研究了它们的光谱性质。1-甲基吲哚衍生物给出了最高的量子产率，并且被观察到作为分子转子，其荧光强度随粘度有明显变化，可能在细胞传感和荧光偏振测定中有应用。
