Dept of Fetal Medicine, Box 228, Rosie Hospital, Cambridge University Hospitals NHS Trust, Cambridge CB2 2SW, UK.
Placenta. 2012 Nov;33(11):893-901. doi: 10.1016/j.placenta.2012.07.011. Epub 2012 Aug 16.
The uterine artery Doppler waveform has been extensively investigated, though its widespread clinical use as a predictor of adverse pregnancy outcome remains under debate. The determinants of the waveform have classically been ascribed to transformation of the spiral arteries and the development of a low resistance uteroplacental circulation, failure of which predisposes to pre-eclampsia, fetal growth restriction and other adverse outcomes. It has become increasingly evident that although spiral artery transformation determines in some part the characteristics of the Doppler waveform, factors pertaining to maternal vascular and endothelial function are also important.
子宫动脉多普勒血流波形已得到广泛研究，尽管其作为预测不良妊娠结局的指标在临床上的广泛应用仍存在争议。该波形的决定因素经典地归因于螺旋动脉的转化和低阻力胎盘循环的发展，其失败易导致子痫前期、胎儿生长受限和其他不良结局。越来越明显的是，尽管螺旋动脉转化在一定程度上决定了多普勒血流波形的特征，但与母体血管和内皮功能相关的因素也很重要。
