UNC Horizons Program, Department of Obstetrics and Gynecology, UNC School of Medicine, University of North Carolina at Chapel Hill, Carrboro, NC.
Department of Family Medicine, Grant Medical Center, Columbus, OH.
Am J Obstet Gynecol. 2014 Apr;210(4):302-310. doi: 10.1016/j.ajog.2013.10.010. Epub 2013 Oct 10.
We review clinical care issues that are related to illicit and therapeutic opioid use among pregnant women and women in the postpartum period and outline the major responsibilities of obstetrics providers who care for these patients during the antepartum, intrapartum, and postpartum periods. Selected patient treatment issues are highlighted, and case examples are provided. Securing a strong rapport and trust with these patients is crucial for success in delivering high-quality obstetric care and in coordinating services with other specialists as needed. Obstetrics providers have an ethical obligation to screen, assess, and provide brief interventions and referral to specialized treatment for patients with drug use disorders. Opioid-dependent pregnant women often can be treated effectively with methadone or buprenorphine. These medications are classified as pregnancy category C medications by the Food and Drug Administration, and their use in the treatment of opioid-dependent pregnant patients should not be considered "off-label." Except in rare special circumstances, medication-assisted withdrawal during pregnancy should be discouraged because of a high relapse rate. Acute pain management in this population deserves special consideration because patients who use opioids can be hypersensitive to pain and because the use of mixed opioid-agonist/antagonists can precipitate opioid withdrawal. In the absence of other indications, pregnant women who use opioids do not require more intense medical care than other pregnant patients to ensure adequate treatment and the best possible outcomes. Together with specialists in pain and addiction medicine, obstetricians can coordinate comprehensive care for pregnant women who use opioids and women who use opioids in the postpartum period.
我们回顾了与孕妇和产后妇女非法和治疗性阿片类药物使用相关的临床护理问题,并概述了在产前、产时和产后期间照顾这些患者的产科提供者的主要责任。突出了选定的患者治疗问题,并提供了案例示例。与这些患者建立牢固的关系和信任对于成功提供高质量的产科护理以及根据需要与其他专家协调服务至关重要。产科提供者有义务对有药物使用障碍的患者进行筛查、评估,并提供简短的干预措施和转介至专门的治疗。依赖阿片类药物的孕妇通常可以用美沙酮或丁丙诺啡有效治疗。这些药物被美国食品和药物管理局归类为妊娠 C 类药物,在治疗依赖阿片类药物的孕妇时不应被视为“超说明书使用”。除非在罕见的特殊情况下,应避免在怀孕期间进行药物辅助戒断,因为戒断复发率很高。应特别考虑该人群的急性疼痛管理,因为使用阿片类药物的患者对疼痛可能更加敏感,并且使用混合阿片类激动剂/拮抗剂可能会引发阿片类药物戒断。在没有其他指征的情况下,使用阿片类药物的孕妇不需要比其他孕妇接受更强化的医疗护理,以确保充分的治疗和尽可能好的结局。与疼痛和成瘾医学专家一起,产科医生可以为使用阿片类药物的孕妇和产后妇女协调全面的护理。