Sritara P, Janvitayanuchit S
Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
J Med Assoc Thai. 1993 Dec;76(12):693-7.
The delivery of aerosol from a metered dose inhaler (MDI) was reported to be more efficient with a spacer. Hence, a home-made spacer modified from a 950 ml low cost plastic bottle, was compared with a MDI and with a 750 ml imported spacer (Nebuhaler). On three consecutive days, at the same time of day, 20 adult patients with chronic asthma inhaled two puffs of terbutaline sulphate (0.5 mg), delivered from MDI alone, MDI with a 750 ml Nebuhlaer and MDI with a home-made spacer. The following measurements were made: forced expiratory volume in one second (FEV1), forced vital capacity (FVC) and pulse rate. These measurements were carried out immediately before and at 5, 20, 60 min after inhalation of terbutaline. FEV1 was significantly increased (P < 0.05) at 5, 20 and 60 min after administration of terbutaline with MDI via either spacers than with MDI alone but no significant difference was observed between Nebuhaler and the home-made spacer. FVC and pulse rate showed no significant change with each method of administration. In conclusion, terbutaline delivered by MDI and home-made spacer was more effective in bronchodilatation than by MDI alone and was just as effective as MDI and Nebuhaler. The home-made spacer therefore offers a simple, inexpensive and more effective method for delivering aerosol drug.
据报道，使用储雾罐时，定量吸入器（MDI）的气雾剂递送效率更高。因此，将一个由950毫升低成本塑料瓶改装而成的自制储雾罐，与一个MDI以及一个750毫升的进口储雾罐（Nebuhaler）进行了比较。连续三天，在每天的同一时间，20名成年慢性哮喘患者吸入了两喷硫酸特布他林（0.5毫克），分别单独通过MDI、搭配750毫升Nebuhlaer的MDI以及搭配自制储雾罐的MDI来递送。进行了以下测量：一秒用力呼气量（FEV1）、用力肺活量（FVC）和脉搏率。这些测量在吸入特布他林之前以及吸入后5分钟、20分钟、60分钟时立即进行。通过任何一种储雾罐使用MDI给药后，在5分钟、20分钟和60分钟时FEV1均显著增加（P < 0.05），相比单独使用MDI，但Nebuhaler和自制储雾罐之间未观察到显著差异。每种给药方法下FVC和脉搏率均无显著变化。总之，通过MDI和自制储雾罐递送的特布他林在支气管扩张方面比单独使用MDI更有效，并且与MDI和Nebuhaler一样有效。因此，自制储雾罐提供了一种简单、廉价且更有效的气雾剂药物递送方法。
