el Kamel A, Slama R, Battikh M, Rouetbi N
Service de Pneumologie, C.H.U. Monastir, Tunisie.
Rev Pneumol Clin. 1995;51(2):73-5.
The aim of this study is to evaluate the ventilatory gain obtained by using metered dose inhaler (MDI) plus spacer versus MDI alone in 30 asthmatic patients (19 men and 11 women); aged 30 to 70 years old. Initial spirometry showed air flow obstruction. A reversibility test was performed with beta 2 agonists: first with MDI and then, later, with MDI plus spacer. In 27 cases (90%) the improvement of FEVI, referring to its initial value, was significantly better with spacer. This improvement was equal or superior to 20% in 19 patients with spacer versus only 9 patients with MDI. The improvement of FEVI was always better with spacer which ever the ways of expressing the bronchodilating response (referring to initial, predicted or absolute value). in conclusion, since the treatment of asthma is now based on local administration of medications, it is recommended to use spacers not only for children and patients who have coordination problems but more widely specially in severe asthma.
本研究的目的是评估在30例哮喘患者（19名男性和11名女性，年龄在30至70岁之间）中，使用定量吸入器（MDI）加储雾罐与单独使用MDI相比所获得的通气增益。初始肺功能检查显示气流阻塞。使用β2激动剂进行了可逆性试验：首先使用MDI，然后使用MDI加储雾罐。在27例（90%）病例中，与初始值相比，使用储雾罐时FEVI的改善明显更好。19例使用储雾罐的患者中，FEVI的改善等于或优于20%，而使用MDI的患者只有9例。无论以何种方式表达支气管扩张反应（参照初始值、预测值或绝对值），使用储雾罐时FEVI的改善总是更好。总之，由于目前哮喘的治疗基于药物的局部给药，建议不仅在儿童和有协调问题的患者中使用储雾罐，而且更广泛地特别是在重度哮喘中使用。
