Horai T
Center for Adult Disease, Osaka, Japan.
Nihon Kyobu Shikkan Gakkai Zasshi. 1990 Nov;28(11):1442-9.
The quantitative changes of glycosaminoglycans in tumor tissue of human lung cancers (6 squamous cell carcinomas, 7 small cell carcinomas and 10 adenocarcinomas) were studied. Normal lung tissues contained of 3.38 mumol uronic acid/g dry weight glycosaminoglycans which consisted of hyaluronic acid, chondroitin sulfates, dermatan sulfate and heparan sulfate. The total amount of glycosaminoglycans in human lung cancer tissues increased 1.7 to 3.5 times in comparison with that in normal lung tissues. The increase in tissue content of glycosaminoglycans was accompanied by an increase in the chondroitin sulfate level in every histologic type of lung cancer, as well as marked increase in hyaluronic acid level in squamous cell carcinomas, and a moderate increase in small cell carcinomas. The concentrations of dermatan sulfate and heparan sulfate in lung cancer tissues did not show any significant changes compared with those in normal lung tissues. The increase in total amount and changes in the composition of glycosaminoglycans in human lung cancer tissue were closely related to the histologic type of the tumor. In adenocarcinomas, some acid glycoprotein with sialic acid was simultaneously detected during the separating course of glycosaminoglycans, which was considered to be derived from mucinous substances related to adenocarcinoma cells.
对人肺癌肿瘤组织（6例鳞状细胞癌、7例小细胞癌和10例腺癌）中糖胺聚糖的定量变化进行了研究。正常肺组织含有3.38微摩尔糖醛酸/克干重的糖胺聚糖，其由透明质酸、硫酸软骨素、硫酸皮肤素和硫酸乙酰肝素组成。与正常肺组织相比，人肺癌组织中糖胺聚糖的总量增加了1.7至3.5倍。糖胺聚糖组织含量的增加伴随着每种组织学类型肺癌中硫酸软骨素水平的增加，以及鳞状细胞癌中透明质酸水平的显著增加和小细胞癌中透明质酸水平的适度增加。与正常肺组织相比，肺癌组织中硫酸皮肤素和硫酸乙酰肝素的浓度没有显示出任何显著变化。人肺癌组织中糖胺聚糖总量的增加和组成的变化与肿瘤的组织学类型密切相关。在腺癌中，在糖胺聚糖的分离过程中同时检测到一些含唾液酸的酸性糖蛋白，其被认为来源于与腺癌细胞相关的粘液物质。
