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撤回:心脏特异性过表达过氧化氢酶可减轻脂多糖诱导的心肌收缩功能障碍:自噬的作用。

RETRACTED: Cardiac-specific overexpression of catalase attenuates lipopolysaccharide-induced myocardial contractile dysfunction: Role of autophagy.

机构信息

Division of Pharmaceutical Sciences, Center for Cardiovascular Research and Alternative Medicine, University of Wyoming College of Health Sciences, Laramie, WY 82071, USA.

Division of Pharmaceutical Sciences, Center for Cardiovascular Research and Alternative Medicine, University of Wyoming College of Health Sciences, Laramie, WY 82071, USA; Department of Physiology, Fourth Military Medical University, Xi'an 710032, China.

出版信息

Free Radic Biol Med. 2012 Sep 15;53(6):1327-1338. doi: 10.1016/j.freeradbiomed.2012.07.084. Epub 2012 Aug 5.

DOI:10.1016/j.freeradbiomed.2012.07.084
PMID:22902401
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3495589/
Abstract

This article has been retracted: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy). This article has been retracted at the request of the Editor-in-Chief. After an institutional investigation into the work of Dr. Jun Ren, University of Wyoming subsequently conducted an examination of other selected publications of Dr. Ren's under the direction of the HHS Office of Research Integrity. Based on the findings of this examination, the University of Wyoming recommended this article be retracted due to concerns regarding data irregularities inconsistent with published conclusions. Specifically, University of Wyoming found evidence of data irregularities and image reuse in Figure 2 that significantly affect the results and conclusions reported in the manuscript.

摘要

本文已被撤回

请参阅爱思唯尔关于文章撤回的政策(http://www.elsevier.com/locate/withdrawalpolicy)。应主编要求,本文已被撤回。怀俄明大学对任军博士的工作进行了机构调查,随后在美国卫生与公众服务部研究诚信办公室的指导下对任军博士的其他选定出版物进行了检查。基于这一检查的结果,怀俄明大学建议撤回这篇文章,原因是数据异常与已发表结论不一致,令人担忧。具体来说,怀俄明大学发现图 2 中存在数据异常和图像重复使用的证据,这严重影响了手稿中报告的结果和结论。

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Cardiac-specific overexpression of catalase attenuates paraquat-induced myocardial geometric and contractile alteration: role of ER stress.心脏特异性过表达过氧化氢酶可减轻百草枯诱导的心肌几何和收缩改变:内质网应激的作用。
Free Radic Biol Med. 2010 Dec 15;49(12):2068-77. doi: 10.1016/j.freeradbiomed.2010.10.686. Epub 2010 Oct 27.
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Autophagy signaling through reactive oxygen species.自噬信号转导通过活性氧。
Antioxid Redox Signal. 2011 Jun;14(11):2215-31. doi: 10.1089/ars.2010.3554. Epub 2011 Mar 9.
4
Cardiac overexpression of insulin-like growth factor 1 attenuates chronic alcohol intake-induced myocardial contractile dysfunction but not hypertrophy: Roles of Akt, mTOR, GSK3beta, and PTEN.心脏过表达胰岛素样生长因子 1 可减轻慢性酒精摄入引起的心肌收缩功能障碍,但不能减轻心肌肥厚: Akt、mTOR、GSK3β 和 PTEN 的作用。
Free Radic Biol Med. 2010 Oct 15;49(7):1238-53. doi: 10.1016/j.freeradbiomed.2010.07.020. Epub 2010 Aug 1.
5
Cardiac overexpression of metallothionein rescues cardiac contractile dysfunction and endoplasmic reticulum stress but not autophagy in sepsis.心肌过表达金属硫蛋白可挽救脓毒症引起的心脏收缩功能障碍和内质网应激,但不能挽救自噬。
J Mol Cell Cardiol. 2010 Feb;48(2):367-78. doi: 10.1016/j.yjmcc.2009.11.003. Epub 2009 Nov 13.
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Decreased catalase expression and increased susceptibility to oxidative stress in primary cultured corneal fibroblasts from patients with granular corneal dystrophy type II.II型颗粒状角膜营养不良患者原代培养角膜成纤维细胞中过氧化氢酶表达降低及对氧化应激的易感性增加。
Am J Pathol. 2009 Jul;175(1):248-61. doi: 10.2353/ajpath.2009.081001. Epub 2009 Jun 4.
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Aldehyde dehydrogenase-2 transgene ameliorates chronic alcohol ingestion-induced apoptosis in cerebral cortex.乙醛脱氢酶-2转基因改善慢性酒精摄入诱导的大脑皮质细胞凋亡。
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