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撤回：Akt2基因敲除通过自噬调节减轻长期热量限制引起的心脏收缩功能变化。

RETRACTED: Akt2 knockout alleviates prolonged caloric restriction-induced change in cardiac contractile function through regulation of autophagy.

作者信息

Zhang Yingmei, Han Xuefeng, Hu Nan, Huff Anna F, Gao Feng, Ren Jun

机构信息

Department of Cardiology, Xijing Hospital, China; Center for Cardiovascular Research and Alternative Medicine, School of Pharmacy, University of Wyoming College of Health Sciences, Laramie, WY 82071, USA.

Center for Cardiovascular Research and Alternative Medicine, School of Pharmacy, University of Wyoming College of Health Sciences, Laramie, WY 82071, USA; Department of Physiology, Fourth Military Medical University, Xi'an 710032, China.

出版信息

J Mol Cell Cardiol. 2014 Jun;71:81-91. doi: 10.1016/j.yjmcc.2013.12.010. Epub 2013 Dec 22.

DOI:10.1016/j.yjmcc.2013.12.010
PMID:24368095
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4076444/
Abstract

This article has been retracted: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy). At the request of the University of Wyoming, this article has been retracted. Although an investigation report from Air Force Medical University found no evidence of misconduct, the University of Wyoming’s institutional investigation of the work authored by Dr. Jun Ren found evidence of data irregularities in Figures 2, 3, and 4 that affect the reported results and conclusions. All authors have been notified of the retraction of this article.

摘要

本文已被撤回

请参阅爱思唯尔的文章撤回政策（http://www.elsevier.com/locate/withdrawalpolicy）。应怀俄明大学的要求，本文已被撤回。尽管空军医科大学的一份调查报告未发现不当行为的证据，但怀俄明大学对任军博士所著论文的机构调查发现，图2、图3和图4中存在数据违规现象，影响了报告的结果和结论。已将本文撤回一事通知了所有作者。

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2
AMP activated protein kinase is indispensable for myocardial adaptation to caloric restriction in mice.腺苷酸活化蛋白激酶对于小鼠热量限制引起的心肌适应是不可或缺的。
PLoS One. 2013;8(3):e59682. doi: 10.1371/journal.pone.0059682. Epub 2013 Mar 19.
3
Adiponectin knockout accentuates high fat diet-induced obesity and cardiac dysfunction: role of autophagy.脂联素基因敲除加剧高脂饮食诱导的肥胖和心脏功能障碍：自噬的作用
Biochim Biophys Acta. 2013 Aug;1832(8):1136-48. doi: 10.1016/j.bbadis.2013.03.013. Epub 2013 Mar 21.
4
Autophagy in human health and disease.自噬与人类健康和疾病
N Engl J Med. 2013 Feb 14;368(7):651-62. doi: 10.1056/NEJMra1205406.
5
Executive summary: heart disease and stroke statistics--2013 update: a report from the American Heart Association.执行摘要：《2013年心脏病和中风统计数据更新：美国心脏协会报告》
Circulation. 2013 Jan 1;127(1):143-52. doi: 10.1161/CIR.0b013e318282ab8f.
6
Akt2 knockout preserves cardiac function in high-fat diet-induced obesity by rescuing cardiac autophagosome maturation.Akt2基因敲除通过挽救心脏自噬体成熟来维持高脂饮食诱导肥胖状态下的心脏功能。
J Mol Cell Biol. 2013 Feb;5(1):61-3. doi: 10.1093/jmcb/mjs055. Epub 2012 Dec 19.
7
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