Mokhtari Behnaz, Yavari Rana, Badalzadeh Reza, Mahmoodpoor Ata
Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Molecular Medicine Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Can J Infect Dis Med Microbiol. 2022 Jun 6;2022:3277274. doi: 10.1155/2022/3277274. eCollection 2022.
Sepsis is defined as a life-threatening organ failure due to dysregulated host response to infection. Despite current advances in our knowledge about sepsis, it is still considered as a major global health challenge. Myocardial dysfunction is a well-defined manifestation of sepsis which is related to worse outcomes in septic patients. Given that the heart is a mitochondria-rich organ and the normal function of mitochondria is essential for successful modulation of septic response, the contribution of mitochondrial damage in sepsis-related myocardial dysfunction has attracted the attention of many scientists. It is widely accepted that mitochondrial damage is involved in sepsis-related myocardial dysfunction; however, effective and potential treatment modalities in clinical setting are still lacking. Mitochondrial-based therapies are potential approaches in sepsis treatment. Although various therapeutic strategies have been used for mitochondrial function improvement, their effects are limited when mitochondria undergo irreversible alterations under septic challenge. Therefore, application of more effective approaches such as mitochondrial transplantation has been suggested. This review highlights the crucial role of mitochondrial damage in sepsis-related myocardial dysfunction, then provides an overview on mitochondrial-based therapies and current approaches to mitochondrial transplantation as a novel strategy, and proposes future directions for more researches in this field.
脓毒症被定义为因宿主对感染的反应失调而导致的危及生命的器官功能衰竭。尽管目前我们对脓毒症的认识有所进展，但它仍然被视为一项重大的全球健康挑战。心肌功能障碍是脓毒症一种明确的表现，与脓毒症患者的不良预后相关。鉴于心脏是富含线粒体的器官，且线粒体的正常功能对于成功调节脓毒症反应至关重要，线粒体损伤在脓毒症相关心肌功能障碍中的作用已引起众多科学家的关注。人们普遍认为线粒体损伤与脓毒症相关心肌功能障碍有关；然而，临床环境中仍缺乏有效且有潜力的治疗方式。基于线粒体的疗法是脓毒症治疗的潜在方法。尽管已采用各种治疗策略来改善线粒体功能，但当线粒体在脓毒症挑战下发生不可逆改变时，其效果有限。因此，有人建议应用更有效的方法，如线粒体移植。本综述强调了线粒体损伤在脓毒症相关心肌功能障碍中的关键作用，接着概述了基于线粒体的疗法以及作为一种新策略的线粒体移植的当前方法，并提出了该领域未来更多研究的方向。
