Shenzhen Key Laboratory of Circular Economy, Shenzhen Graduate School, Peking University, Shenzhen 518055, China.
Sci Total Environ. 2012 Oct 15;437:10-4. doi: 10.1016/j.scitotenv.2012.07.056. Epub 2012 Aug 17.
The present study measured eight PBDE congeners' (BDE-28, 47, 99, 100, 153, 154, 183, and 209) exposure via ingestion of indoor dust and soil, inhalation, and food consumption. Contributions to PBDEs exposure from different media revealed that indoor dust (dust suspended in air) was not an important exposure route for PBDE congeners for adults in Shenzhen, China. Food consumption contributed more to daily intake of Σ(8)BDE, especially for lower-brominated PBDE congeners. Based on calculated average total daily intake, hazard quotients were determined to estimate the non-cancer risks of PBDE exposure. Meanwhile, cancer risk was also estimated assuming that the oral cancer slope factors of all PBDE congeners are equipotent as BDE-209. The hazard quotients ranged from 1.2×10(-5) (BDE-209) to 2.0×10(-2) (BDE-47), suggesting a low deleterious risk with regard to PBDEs. The cancer risk value ranged from 1.1×10(-24) to 5.5×10(-21) implying that the total risks due to exposure to PBDEs via all exposure routes are extremely low for adults.
本研究通过摄入室内灰尘和土壤、吸入和食物消费来测量八种多溴二苯醚同系物（BDE-28、47、99、100、153、154、183 和 209）的暴露情况。不同介质对 PBDEs 暴露的贡献表明，室内灰尘（悬浮在空气中的灰尘）不是中国深圳成年人接触 PBDE 同系物的重要途径。食物消费对每日Σ（8）BDE 的摄入量贡献更大，特别是对低溴代 PBDE 同系物。基于计算得出的平均每日总摄入量，确定危害系数以估计 PBDE 暴露的非癌症风险。同时，还假设所有 PBDE 同系物的口腔癌症斜率因子都与 BDE-209 等效，以此来估算癌症风险。危害系数范围从 1.2×10(-5)（BDE-209）到 2.0×10(-2)（BDE-47），表明 PBDEs 的有害风险较低。癌症风险值范围从 1.1×10(-24)到 5.5×10(-21)，这意味着通过所有暴露途径接触 PBDEs 而产生的总风险对成年人来说极低。
