基于社区的衰老和阿尔茨海默病有氧运动试验方法。
A community-based approach to trials of aerobic exercise in aging and Alzheimer's disease.
机构信息
Dept. of Neurology, University of Kansas Medical Center, Kansas City, KS, USA.
出版信息
Contemp Clin Trials. 2012 Nov;33(6):1105-16. doi: 10.1016/j.cct.2012.08.002. Epub 2012 Aug 7.
Abstract
The benefits of exercise for aging have received considerable attention in both the popular and academic press. The putative benefits of exercise for maximizing cognitive function and supporting brain health have great potential for combating Alzheimer's disease (AD). Aerobic exercise offers a low-cost, low-risk intervention that is widely available and may have disease modifying effects. Demonstrating that aerobic exercise alters the AD process would have enormous public health implications. The purpose of this paper is to report the protocol of a current, community-based pilot study of aerobic exercise for AD to guide future investigation. This manuscript provides 1) an overview of possible benefits of exercise in those with dementia, 2) a rationale and recommendations for implementation of a community-based approach, 3) recommendation for implementation of similar study protocols, and 4) unique challenges in conducting an exercise trial in AD.
摘要
锻炼对衰老的益处已在大众和学术媒体中受到广泛关注。锻炼对最大限度地提高认知功能和支持大脑健康的潜在益处，为对抗阿尔茨海默病（AD）提供了巨大的潜力。有氧运动是一种低成本、低风险的干预措施，广泛可用，并且可能具有疾病改善作用。证明有氧运动改变 AD 进程将具有巨大的公共卫生意义。本文的目的是报告一项针对 AD 患者进行有氧运动的当前基于社区的试点研究方案，以指导未来的研究。本文提供了 1）锻炼对痴呆患者的潜在益处概述，2）实施基于社区方法的原理和建议，3）实施类似研究方案的建议，以及 4）在 AD 中进行锻炼试验的独特挑战。
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