Fabian Carol J, Klemp Jennifer R, Marchello Nicholas J, Vidoni Eric D, Sullivan Debra K, Nydegger Jennifer L, Phillips Teresa A, Kreutzjans Amy L, Hendry Bill, Befort Christie A, Nye Lauren, Powers Kandy R, Hursting Stephen D, Giles Erin D, Hamilton-Reeves Jill M, Li Bing, Kimler Bruce F
Department of Internal Medicine, Division of Medical Oncology, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA.
Department of Nutrition, Kinesiology, and Psychological Sciences, University of Central Missouri, P.O. Box 800, Warrensburg, MO 64093, USA.
Cancers (Basel). 2021 Sep 28;13(19):4871. doi: 10.3390/cancers13194871.
Aerobic exercise reduces risk for breast cancer and recurrence and promotes visceral adipose tissue (VAT) loss in obesity. However, few breast cancer survivors achieve recommended levels of moderate to vigorous physical activity (MVPA) without supervision. In a two-cohort study, feasibility of 12 weeks of partially supervised exercise was started concomitantly with caloric restriction and effects on body composition and systemic risk biomarkers were explored. In total, 22 obese postmenopausal sedentary women (including 18 breast cancer survivors) with median age of 60 and BMI of 37 kg/m were enrolled. Using personal trainers twice weekly at area YMCAs, MVPA was escalated to ≥200 min/week over 9 weeks. For cohort 2, maintenance of effect was assessed when study provided trainer services were stopped but monitoring, group counseling sessions, and access to the exercise facility were continued. Median post-escalation MVPA was 219 min/week with median 12-week mass and VAT loss of 8 and 19%. MVPA was associated with VAT loss which was associated with improved adiponectin:leptin ratio. In total, 9/11 of cohort-2 women continued the behavioral intervention for another 12 weeks without trainers. High MVPA continued with median 24-week mass and VAT loss of 12 and 29%. This intervention should be further studied in obese sedentary women.
有氧运动可降低患乳腺癌的风险及复发率，并促进肥胖患者内脏脂肪组织（VAT）的减少。然而，很少有乳腺癌幸存者在没有监督的情况下达到推荐的中等至剧烈身体活动（MVPA）水平。在一项双队列研究中，在进行热量限制的同时开始了为期12周的部分监督运动的可行性研究，并探讨了其对身体成分和全身风险生物标志物的影响。总共招募了22名肥胖的绝经后久坐不动的女性（包括18名乳腺癌幸存者），中位年龄为60岁，BMI为37kg/m²。在当地基督教青年会每周使用私人教练两次，在9周内将MVPA增加到≥200分钟/周。对于队列2，当研究提供的教练服务停止但监测、小组咨询会议和使用健身设施的机会继续存在时，评估效果的维持情况。升级后的MVPA中位数为219分钟/周，12周时体重和VAT的中位数减少分别为8%和19%。MVPA与VAT减少相关，而VAT减少与脂联素：瘦素比值的改善相关。队列2中的11名女性中有9名在没有教练的情况下继续进行了另外12周的行为干预。高MVPA持续存在，24周时体重和VAT的中位数减少分别为12%和29%。这种干预措施应在肥胖的久坐女性中进一步研究。
