Department of Neurology, University of Kansas School of Medicine, Kansas City, Kansas 66160, USA.
Int J Neurosci. 2011 Aug;121(8):450-6. doi: 10.3109/00207454.2011.574762. Epub 2011 May 17.
The purpose of this study was to determine the reliability of treadmill peak exercise testing in people with very mild-to-mild Alzheimer disease (AD).
Sixteen subjects with very mild-to-mild AD performed graded peak treadmill exercise tests twice within a 14-day period. Heart rate, oxygen consumption, and respiratory exchange ratio (RER) were continuously monitored. Peak values were analyzed for absolute level of agreement.
Fourteen participants (87.5%) completed testing. Reliability was excellent with total peak oxygen consumption (VO2peak) (ml/kg/min) highly correlated across the two tests (r = 0.94, p < .001) with an intraclass correlation coefficient (ICC[3,1]) of 0.92 (95% confidence interval (CI) = 0.78, 0.97). The standard error of measurement (SEM) for VO2peak was 1.29 (95% CI = 0.88, 1.89).
These results indicate that peak exercise testing on a treadmill is reliable in the early stages of AD.
本研究旨在确定在轻度至极轻度阿尔茨海默病（AD）患者中进行跑步机峰值运动测试的可靠性。
16 名轻度至极轻度 AD 患者在 14 天内进行了两次分级峰值跑步机运动测试。连续监测心率、耗氧量和呼吸交换比（RER）。分析峰值的绝对一致性。
14 名参与者（87.5%）完成了测试。总峰值摄氧量（VO2peak）（ml/kg/min）在两次测试中高度相关（r = 0.94，p<.001），组内相关系数（ICC[3,1]）为 0.92（95%置信区间[CI] = 0.78, 0.97）。VO2peak 的测量标准误差（SEM）为 1.29（95%CI = 0.88, 1.89）。
这些结果表明，在 AD 的早期阶段，跑步机上的峰值运动测试是可靠的。
